Taking the pulse of aging: Mapping pulse pressure and elasticity in cerebral arteries with optical methods

被引：61

作者：

Fabiani, Monica ^{[1
,2
,3
,4
]}

Low, Kathy A. ^{[1
]}

Tan, Chin-Hong ^{[1
,2
]}

Zimmerman, Benjamin ^{[1
,4
]}

Fletcher, Mark A. ^{[1
,4
]}

Schneider-Garces, Nils ^{[1
,2
]}

Maclin, Edward L. ^{[1
]}

Chiarelli, Antonio M. ^{[1
]}

Sutton, Bradley P. ^{[1
,3
,4
]}

Gratton, Gabriele ^{[1
,2
,3
,4
]}

机构：

[1] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Psychol, Urbana, IL 61801 USA

[3] Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA

[4] Univ Illinois, Neurosci Program, Urbana, IL 61801 USA

来源：

PSYCHOPHYSIOLOGY | 2014年 / 51卷 / 11期

关键词：

Aging; Cerebrovascular health; Arterial compliance; Cardiorespiratory fitness (CRF); Noninvasive optical imaging; Brain anatomy; MILD COGNITIVE IMPAIRMENT; NEAR-INFRARED SPECTROSCOPY; WHITE-MATTER INTEGRITY; OLDER-ADULTS; CARDIORESPIRATORY FITNESS; ALZHEIMERS-DISEASE; PHYSICAL-ACTIVITY; INTELLECTUAL IMPAIRMENT; AEROBIC FITNESS; CAROTID-ARTERY;

D O I：

10.1111/psyp.12288

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Cerebrovascular support is crucial for healthy cognitive and brain aging. Arterial stiffening is a cause of reduced brain blood flow, a predictor of cognitive decline, and a risk factor for cerebrovascular accidents and Alzheimer's disease. Arterial health is influenced by lifestyle factors, such as cardiorespiratory fitness (CRF). We investigated new noninvasive optical measures of cerebrovascular health, which provide estimates of arterial pulse parameters (pulse pressure, transit time, and compliance/elasticity) within specific cerebral arteries and cortical regions, and low-resolution maps of large superficial cerebral arteries. We studied naturally occurring variability in these parameters in adults (aged 55-87), and found that these indices of cerebrovascular health are negatively correlated with age and positively with CRF and gray and white matter volumes. Further, regional pulse transit time predicts specific neuropsychological performance.

引用

页码：1072 / 1088

页数：17

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