EVALUATION OF SERUM OSTEOCALCIN IN ELDERLY PATIENTS WITH TYPE-2 DIABETES MELLITUS

被引：0

作者：

Gradinaru, Daniela ^{[1
]}

Mitrea, Niculina ^{[1
]}

Margina, Denisa ^{[1
]}

Arsene, Andreea L. ^{[1
]}

Gruia, Vlad ^{[1
]}

Dragoi, Cristina ^{[1
]}

Nicolae, Alina ^{[1
]}

Borsa, Claudia ^{[2
]}

Gherasim, Petre ^{[2
]}

机构：

[1] Univ Med & Pharm Carol Davila, Dept Biochem, Fac Pharm, Bucharest 020956 2, Romania

[2] Ana Aslan Nat Inst Gerontol & Geriatr, Bucharest, Romania

来源：

FARMACIA | 2009年 / 57卷 / 03期

关键词：

type-2 diabetes mellitus (DM2); elderly; osteocalcin (OST); BONE TURNOVER; GLA-PROTEIN; INSULIN; METABOLISM; MARKERS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Osteocalcin, the second most abundant protein in bone tissue after collagen, is secreted by osteoblasts and thought to participate in mineralization and calcium ion homeostasis. In addition to its use as biomarker in ostoporosis, experimental studies on mice published in Cell journal revealed for osteocalcin new metabolic functions, as hormone, being involved in blood glucose regulation, in insulin secretion, and in adipose tissue shaping. The aim of this study, conducted on 85 elderly patients (21 males and 64 females, aged 63-78 years) was to examine the relationship between serum osteocalcin concentration and classical biomarkers of investigation for glucose and lipid metabolism, using data from a clinical evaluation in elderly patients with impaired glucose tolerance and type-2 diabetes mellitus.

引用

页码：331 / 338

页数：8

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