Structural requirements of heparin and related molecules to exert a multitude of anti-inflammatory activities

被引：24
作者：
Ludwig, Ralf J.
Alban, Susanne
Boehncke, Wolf-Henning
机构：
[1] Univ Frankfurt Klinikum, Dept Dermatol, D-6000 Frankfurt, Germany
[2] Univ Kiel, Inst Pharmaceut, Kiel, Germany
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 09期
关键词：
inflammation; anti-inflammatory agents; heparin; glycosaminoglycans; receptors; lymphocyte homing; chemokines; angiogenesis; complement;
D O I：
10.2174/138955706778195180
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chronic inflammatory diseases are common and still remain a therapeutic challenge for both efficacy and safety reasons. Hence, novel therapeutics addressing these issues would for example improve treatment of severe diseases such as psoriasis, rheumatoid arthritis, inflammatory bowel disease and multiple sclerosis. Inappropriate leukocyte homing to the affected compartments is a common feature of these diseases. Heparin and related polysaccharides have been shown to interfere with leukocyte homing through a variety of effects distinct from their anticoagulant properties. In this review, data on heparin as an anti-inflammatory agent are presented. In addition, structure-activity requirements for the anti-inflammatory properties of heparin are discussed, which should aid the drug development based on structurally modified heparin or other sulfated carbohydrates for treatment of inflammatory diseases.
引用
收藏
页码：1009 / 1023
页数：15
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