White matter ischaemia

被引:45
作者
Petty, MA [1 ]
Wettstein, JG [1 ]
机构
[1] Hoechst Marion Roussel, CNS Res, Bridgewater, NJ 08807 USA
关键词
brain; spinal cord; ischaemia;
D O I
10.1016/S0165-0173(99)00025-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Brain and spinal cord while matter are vulnerable to the effects of ischaemia. Reduction of the energy supply leads to a cascade of events including depolarization, influx of Na+ and the subsequent reverse operation of the membrane protein the Na+/Ca2+ exchanger which ultimately terminates in intracellular Ca2+ overload and irreversible axonal injury. Various points along the white matter damage cascade could be specifically targeted as a potential means of inhibiting the development of axonal irreversible injury. (C) 1999 Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码:58 / 64
页数:7
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