Increased Prevalence of Regulatory T-Cells in the Peripheral Blood of Patients with Gastrointestinal Cancer

被引：0

作者：

Tokuno, Kazuhisa ^{[1
]}

Hazama, Shoichi ^{[1
]}

Yoshino, Shigefumi ^{[1
]}

Yoshida, Shin ^{[1
]}

Oka, Masaaki ^{[1
]}

机构：

[1] Yamaguchi Univ, Grad Sch Med, Dept Surg 2, Dept Digest Surg & Surg Oncol, Yamaguchi 7558505, Japan

来源：

ANTICANCER RESEARCH | 2009年 / 29卷 / 05期

关键词：

Regulatory T-cell; FoxP3; gastrointestinal cancer; TRANSCRIPTION FACTOR FOXP3; IMMUNOLOGICAL-TOLERANCE; INCREASED POPULATIONS; ESOPHAGEAL CANCERS; TUMOR-IMMUNITY; LUNG-CANCER; INDUCTION; ADENOCARCINORNA; AUTOIMMUNITY; LYMPHOCYTES;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Although recent studies have shown that FoxP3 represent the most specific Treg marker only a few studies have reported on the presence of FoxP3(+)Treg in peripheral blood. Patients and Methods: Peripheral blood mononuclear cells (PBMC) were harvested from 37 healthy volunteers and 94 patients with gastrointestinal cancer. The prevalence of Treg co-expressing CD4(+)FoxP3(+) was analyzed using flow cytometry. Results: The prevalence of Treg in the peripheral blood of gastrointestinal cancer patients was significantly higher than that in healthy volunteers (p=0.012). In early stage I cancer, Treg levels tended to be higher than those in healthy volunteers (p=0.069); these levels were significantly reduced after tumor resection (p=0.0027). Conclusion: The prevalence of Treg was increased in patients with gastrointestinal cancer, even in the early stages of the disease. Since Treg levels decreased after curative resection, it is possible that tumor cells may have induced and expanded the Treg pool.

引用

页码：1527 / 1532

页数：6

共 39 条

[1] Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells [J].