Tissue Dissolution by a Novel Multisonic Ultracleaning System and Sodium Hypochlorite

Introduction: This study aimed to evaluate the effectiveness of a novel Multisonic Ultracleaning System (Sonendo Inc, Laguna Hills, CA) in tissue dissolution in comparison with conventional irrigation. devices. Methods: Pieces of bovine muscle tissue (68 +/- 2 mg) were placed in 0.7-mL test tubes (height: 23.60 mm, inner diameter: 6.00 mm, outer diameter: 7.75 mm) and exposed to 5 minutes of irrigation by different devices. Endodontic devices included the Multisonic Ultracleaning System, the Piezon Master 700 (EMS, Dallas, TX) ultrasonic system with agitation, the Endo Vac negative-pressure irrigation system (SybronEndo, Orange, CA), and a conventional positive-pressure 27-G irrigation needle at a flow rate of 10 mUmin. The systems were tested with 0.5%, 3%, and 6% sodium hypochlorite (NaOCl) at room temperature (21 degrees C) as well as 40 degrees C. Irrigation with sterile water was used as a control. The mass of tissue specimens was measured and recorded before and after the use of each device, and if the specimen was completely dissolved visually within 5 minutes, the dissolution time was recorded. The rate of tissue dissolution (%/s) was then calculated. Results: The Multisonic Ultracleaning System had the fastest rate of tissue dissolution (P < .05), at 1.0% 0.1% per second using 0.5% NaOCl, 2.3% 0.9% per second using 3% NaOCl, and 2.9% 0.7% per second using 6% NaOCl. This tissue dissolution rate was more than 8 times greater than the second fastest device tested (P < .01), the Piezon Master 700 ultrasonic system, which resulted in a tissue dissolution rate of 0.328% 0.002% per second using 6% NaOCl at 40 degrees C. For all irrigation devices tested, the rate of tissue dissolution increased with a higher concentration and temperature of the NaOCl solution. Conclusions: The novel Multisonic Ultracleaning System achieved a significantly faster tissue dissolution rate when compared with the other systems examined