Fos Expression in the Rat Vestibular Nucleus Complex after Plugging the Three Semicircular Canals

被引：0
作者：
Chen, Bin
Yu, Dongzhen
Chen, Zhengnong
Yin, Shankai [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Otolaryngol, Shanghai 200233, Peoples R China
来源：
AUDIOLOGY AND NEURO-OTOLOGY | 2009年 / 14卷 / 04期
关键词：
Fos expression; Semicircular canal plugging; Vestibular compensation; Vestibular nucleus complex; HIGH-ACCELERATION ROTATIONS; BRAIN-STEM; VESTIBULOOCULAR REFLEX; UNILATERAL LABYRINTHECTOMY; PROTEIN EXPRESSION; SQUIRREL-MONKEY; GUINEA-PIGS; COMPENSATION; OCCLUSION; DYNAMICS;
D O I：
10.1159/000189263
中图分类号：
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号：
100104 ; 100213 ;
摘要：
Hypothesis: Differential compensation after unilateral semicircular canal plugging (UCP) and unilateral labyrinthectomy (UL) may involve different expression patterns of fos mRNA and Fos protein in the vestibular nucleus complex. Background: The expression of Fos protein in the vestibular nuclei underwent spatiotemporal changes related to the compensation process following surgical UL and chemical UL. These changes were temporally related to the appearance and development of vestibular compensation in the rat. Methods: Spatiotemporal changes in both fos mRNA and protein levels in the rat brain after UCP were observed. The Fos expression pattern after UCP was compared to that after UL. Results: Greater fos mRNA and Fos protein expressions were detected in bilateral medial vestibular nuclei (MVNs) after UL than after UCP. The changes were relatively long-lived after UL compared to those following UCP. Conclusion: Differences in the expression pattern of fos mRNA and Fos protein in bilateral MVNs between UCP and UL may explain differences in compensation after UCP and UL.
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收藏
页码：209 / 213
页数：5
相关论文
共 27 条
  • [1] VESTIBULO-OCULAR REFLEXES AFTER SELECTIVE PLUGGING OF THE SEMICIRCULAR CANALS IN THE MONKEY - RESPONSE PLANE DETERMINATIONS
    BOHMER, A
    HENN, V
    SUZUKI, J
    [J]. BRAIN RESEARCH, 1985, 326 (02) : 291 - 298
  • [2] The dynamics of the vestibulo-ocular reflex after peripheral vestibular damage - I. Frequency-dependent asymmetry
    Broussard, DM
    Bhatia, JK
    Jones, GEG
    [J]. EXPERIMENTAL BRAIN RESEARCH, 1999, 125 (03) : 353 - 364
  • [3] c-fos expression in the rat brain after unilateral labyrinthectomy and its relation to the uncompensated and compensated stages
    Cirelli, C
    Pompeiano, M
    DAscanio, P
    Arrighi, P
    Pompeiano, O
    [J]. NEUROSCIENCE, 1996, 70 (02) : 515 - 546
  • [4] Darlington CL, 1996, BRAIN RES, V735, P173
  • [5] Duflo SGD, 1999, BRAIN RES, V824, P1
  • [6] Hashimoto T, 2000, NEUROSCIENCE, V95, P1003
  • [7] Combining sensory information: Mandatory fusion within, but not between, senses
    Hillis, JM
    Ernst, MO
    Banks, MS
    Landy, MS
    [J]. SCIENCE, 2002, 298 (5598) : 1627 - 1630
  • [8] KAUFMAN GD, 1992, J NEUROSCI, V12, P4489
  • [9] Correlation of Fos expression and circling asymmetry during gerbil Vestibular compensation
    Kaufman, GD
    Shinder, ME
    Perachio, AA
    [J]. BRAIN RESEARCH, 1999, 817 (1-2) : 246 - 255
  • [10] Effect of MK801 on cFos-like protein expression in the medial vestibular nucleus at early stage of vestibular compensation in uvulonodullectomized rats
    Kim, MS
    Jin, BK
    Chun, SW
    Lee, MY
    Lee, SH
    Kim, JH
    Park, BR
    [J]. NEUROSCIENCE LETTERS, 1997, 231 (03) : 147 - 150
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