Computational Study of Hemodynamic Effects of Abnormal E/A Ratio on Left Ventricular Filling

被引：1

作者：

Zheng, Xudong ^{[1
]}

Xue, Qian ^{[1
]}

Mittal, Rajat ^{[2
]}

机构：

[1] Univ Maine, Dept Mech Engn, Orono, ME 04473 USA

[2] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA

来源：

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME | 2014年 / 136卷 / 06期

基金：

美国国家科学基金会;

关键词：

diastolic heart dysfunction; hemodynamics; left ventricular filling; biomechanics; VORTEX RING FORMATION; FLOW; HEART; DYNAMICS; QUANTIFICATION;

D O I：

10.1115/1.4027268

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Three-dimensional numerical simulations are employed to investigate the hemodynamic effects of abnormal E/A ratios on left ventricular filling. The simulations are performed in a simplified geometric model of the left ventricle (LV) in conjunction with a specified endocardial motion. The model has been carefully designed to match the important geometric and flow parameters under the physiological conditions. A wide range of E/A ratios from 0 to infinity is employed with the aim to cover all the possible stages of left ventricle diastolic dysfunction (DD). The effects of abnormal E/A ratios on vortex dynamics, flow propagation velocity, energy consumption as well as flow transport and mixing are extensively discussed. Our results are able to confirm some common findings reported by the previous studies, and also uncover some interesting new features.

引用

页数：10

共 43 条

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