Hepatocyte growth factor in renal disease: cause or cure?

被引：6
|
作者：
Laping, NJ [1 ]
机构：
[1] SmithKline Beecham Pharmaceut, Renal Pharmacol, King Of Prussia, PA 19406 USA
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 1999年 / 56卷 / 5-6期
关键词：
hepatocyte growth factor; c-met; renal disease; diabetes; glomerulosclerosis;
D O I：
10.1007/s000180050438
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hepatocyte growth factor (HGF) is an injury-released growth factor with diverse effects on epithelial and endothelial cells. These effects include proliferation, migration, extracellular matrix production and tubulogenesis. These activities allow HGF to function as an organizer of repair processes that bring about restoration of tubular function following renal injury. However, while HGF has been demonstrated to accelerate recovery of renal function after an acute insult. prolonged exposure to elevated levels of HGF can reduce renal function and may contribute to progressive renal disease. This review will describe the cellular activities of HGF, how they pertain to renal repair and the therapeutic application of regulating HGF activity in acute versus chronic renal disease.
引用
收藏
页码：371 / 377
页数：7
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