Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation

被引：56
作者：
Liu, Xuan
Huang, Wei
Li, Chufang
Li, Ping
Yuan, Jing
Li, Xiaorong
Qiu, Xiao-Bo
Ma, Oingjun
Cao, Cheng [1 ]
机构：
[1] Beijing Inst Technol, Beijing 100850, Peoples R China
[2] Pekin Union Med Coll, Inst Basic Med Sci, Beijing 100005, Peoples R China
来源：
MOLECULAR CELL | 2006年 / 22卷 / 03期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.molcel.2006.04.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Proteasome-mediated proteolysis is a primary protein degradation pathway in cells. The present study demonstrates that c-AbI and Arg (abi-related gene)tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (alpha 4) subunit at Tyr-153. Consequently, proteasome-dependent proteolysis is compromised. Notably, cells expressing a phosphorylation mutant of PSMA7(Y153F) display impaired G1/S transition and S/G2 progression, highlighting the biological significance of tyrosine phosphorylation of a proteasome subunit as an important cellular regulatory control.
引用
收藏
页码：317 / 327
页数：11
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