Synthesis of a novel lipophilic gadolinium complex as a potential MRI contrast agent

被引：3
作者：
Masotti, Andrea
Remollino, Laura
Carafa, Maria
Marianecci, Carlotta
Santucci, Eleonora
Ortaggi, Giancarlo
机构：
[1] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy
[2] Univ GD Annunzio, Fac Pharm, Dept Sci Farmaco, I-66100 Chieti, Italy
[3] Univ Roma La Sapienza, Fac Pharm, Dept Studi Chim & Tecnol Sostanze Biologicamente, I-00185 Rome, Italy
来源：
SYNLETT | 2006年 / 17期
关键词：
contrast agent; gadolinium complex; mixed micelles; magnetic resonance imaging; magnetic resonance angiography;
D O I：
10.1055/s-2006-950281
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of a novel lipophilic diethylentriamino-tetracetic(DTTA)-dodecane gadolinium complex is reported. The Gd-DTTA-dodecane complex is able to form mixed micelles with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPQ and a nonionic surfactant like Tween 80. This novel multicomponent system can find potential application in magnetic resonance angiography (MP,A).
引用
收藏
页码：2815 / 2817
页数：3
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