SB-203207 and SB-203208, two novel isoleucyl tRNA synthetase inhibitors from a Streptomyces sp II.: Structure determination

被引：47

作者：

Houge-Frydrych, CSV ^{[1
]}

Gilpin, ML ^{[1
]}

Skett, PW ^{[1
]}

Tyler, JW ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Harlow CM19 5AW, Essex, England

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 04期

关键词：

D O I：

10.7164/antibiotics.53.364

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two novel isoleucyl tRNA synthetase inhibitors, SE-203207 and SE-203208 have been isolated from a Streptomyces sp. and found to be structurally related to altemicidin. Structures of SE-203207 and SE-203208 have been deduced by a combination of spectroscopic techniques, derivatisation, hydrolysis studies and found to be 4-(aminocarbonyl)-7-{[(2-amino-3 -methylpentanoyl)aminosulphonyl]acetamido}-2,4a,5,6,7,7a-hexahydro-6-hydroxy-2-methyl-1H-2-pyrindine-7-carboxylic acid (1) and 4-(aminocarbonyl)-7-{[(2-amino-3-methyl pentanoyl)-aminosulphonyl]acetamido}-2,4a,5,6,7,7a-hexahydro-6-(2-amino-3-phenylbutanoyl oxy)-2-methyl-1H-2-pyrindine-7-carboxylic acid (2), respectively.

引用

页码：364 / 372

页数：9

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