Rhodium-Catalyzed Chemo-, Regio-, and Enantioselective Allylation of 2-Aminothiazoles with Terminal Allenes

被引：7

作者：

Zheng, Jun ^{[1
]}

Woerl, Benjamin ^{[1
]}

Breit, Bernhard ^{[1
]}

机构：

[1] Albert Ludwigs Univ Freiburg, Inst Organ Chem, Albertstr 21, D-79104 Freiburg, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 31-32期

关键词：

2-Aminobenzothiazoles; Terminal allenes; Rhodium; Asymmetric catalysis; Allylation; DESIGN; REGIODIVERGENT; DERIVATIVES; INHIBITORS; ALKYNES;

D O I：

10.1002/ejoc.201900435

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rhodium-catalyzed chemo-, regio- and enantioselective intermolecular coupling reaction of 2-aminobenzothiazoles with terminal allenes is reported. The new reaction displays a wide substrate scope for both reaction partners to deliver the allylation products in good yields, with excellent regio- and enantioselectivity. This novel methodology was further applied in an efficient synthesis of chiral isothiourea.

引用

页码：5180 / 5182

页数：3

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