Differentiation of human innate lymphoid cells (ILCs)

被引：55

作者：

Juelke, Kerstin ^{[1
]}

Romagnani, Chiara ^{[1
]}

机构：

[1] Deutsch Rheuma Forschungszentrum DRFZ Berlin, Innate Immun, Berlin, Germany

来源：

CURRENT OPINION IN IMMUNOLOGY | 2016年 / 38卷

关键词：

NATURAL-KILLER-CELLS; ROR-GAMMA-T; TRANSCRIPTION FACTOR GATA3; NK CELLS; DENDRITIC CELLS; LINEAGE RELATIONSHIPS; CD56(BRIGHT) CELLS; UNIQUE SUBSET; PEYERS PATCH; HUMAN SKIN;

D O I：

10.1016/j.coi.2015.11.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During the last years, a high complexity in innate lymphoid lineages now collectively referred to as innate lymphoid cells (ILCs) has been revealed. ILCs can be grouped according to their effector functions and transcriptional requirements into three main groups, termed group 1, 2 and 3 ILCs. The differentiation of ILC lineages from hematopoietic precursors and the molecular switches guiding their developmental fate have started to be characterized both in mice and humans. In this review, we discuss the origin, differentiation stages and plasticity of human ILC subsets as well as the signals that drive ILC lineage commitment and acquisition of their unique effector programs.

引用

页码：75 / 85

页数：11

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