Tools and methods for studying the Drosophila JAK/STAT pathway

被引：30
作者：
Chen, Qian [1 ]
Giedt, Michelle [1 ]
Tang, Lingfeng [1 ]
Harrison, Douglas A. [1 ]
机构：
[1] Univ Kentucky, Dept Biol, Lexington, KY 40506 USA
来源：
METHODS | 2014年 / 68卷 / 01期
基金：
美国国家科学基金会;
关键词：
Janus kinase (JAK); STAT; Cytokine; Drosophila; Cell signaling; Genetics; CELL SELF-RENEWAL; PROTEIN-TYROSINE-PHOSPHATASE; JANUS KINASE/SIGNAL TRANSDUCER; JAK-STAT PATHWAY; SEX-DETERMINATION; GENE-EXPRESSION; STEM-CELLS; SIGNALING COMPONENTS; FEEDBACK INHIBITION; NEGATIVE REGULATION;
D O I：
10.1016/j.ymeth.2014.03.023
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) signaling pathway is one of a limited number of signaling cascades that is extensively utilized for many developmental and homeostatic functions. The JAK/STAT pathway is evolutionarily conserved from insects to mammals, with homologous transduction machinery in each. Yet the mammalian pathway is composed of multiple members for each family of proteins, while flies have only a single homologue of most pathway components. This simplicity and the abundance of genetic, biochemical, and developmental tools make Drosophila an attractive model to investigate this important signaling pathway. This review provides a basic description of the Drosophila JAK/STAT cascade and summarizes currently available reagents and tools to study and manipulate the pathway. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：160 / 172
页数：13
相关论文
共 164 条
[11]   Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila [J].
Baeg, GH ;
Zhou, R ;
Perrimon, N .
GENES & DEVELOPMENT, 2005, 19 (16) :1861-1870
[12]   The Drosophila STAT protein, Stat92E, regulates follicle cell differentiation during oogenesis [J].
Baksa, K ;
Parke, T ;
Dobens, LL ;
Dearolf, CR .
DEVELOPMENTAL BIOLOGY, 2002, 243 (01) :166-175
[13]  
Bausek Nina, 2013, JAKSTAT, V2, pe25686, DOI 10.4161/jkst.25686
[14]   A Drosophila PIAS homologue negatively regulates stat92E [J].
Betz, A ;
Lampen, N ;
Martinek, S ;
Young, MW ;
Darnell, JE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (17) :9563-9568
[15]   STRIPE-SPECIFIC REGULATION OF PAIR-RULE GENES BY HOPSCOTCH, A PUTATIVE JAK FAMILY TYROSINE KINASE IN DROSOPHILA [J].
BINARI, R ;
PERRIMON, N .
GENES & DEVELOPMENT, 1994, 8 (03) :300-312
[16]   JAK/STAT autocontrol of ligand-producing cell number through apoptosis [J].
Borensztejn, Antoine ;
Boissoneau, Elisabeth ;
Fernandez, Guillaume ;
Agnes, Francois ;
Pret, Anne-Marie .
DEVELOPMENT, 2013, 140 (01) :195-204
[17]   Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis [J].
Boyle, Monica ;
Wong, Chihunt ;
Rocha, Michael ;
Jones, D. Leanne .
CELL STEM CELL, 2007, 1 (04) :470-478
[18]   JAK/STAT signalling in Drosophila controls cell motility during germ cell migration [J].
Brown, S ;
Zeidler, MP ;
Hombría, JECG .
DEVELOPMENTAL DYNAMICS, 2006, 235 (04) :958-966
[19]   Novel level of signalling control in the JAK/STAT pathway revealed by in situ visualisation of protein-protein interaction during Drosophila development [J].
Brown, S ;
Hu, N ;
Hombría, JCG .
DEVELOPMENT, 2003, 130 (14) :3077-3084
[20]   Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless [J].
Brown, S ;
Hu, N ;
Hombría, JCG .
CURRENT BIOLOGY, 2001, 11 (21) :1700-1705
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