Tools and methods for studying the Drosophila JAK/STAT pathway

被引：30
作者：
Chen, Qian [1 ]
Giedt, Michelle [1 ]
Tang, Lingfeng [1 ]
Harrison, Douglas A. [1 ]
机构：
[1] Univ Kentucky, Dept Biol, Lexington, KY 40506 USA
来源：
METHODS | 2014年 / 68卷 / 01期
基金：
美国国家科学基金会;
关键词：
Janus kinase (JAK); STAT; Cytokine; Drosophila; Cell signaling; Genetics; CELL SELF-RENEWAL; PROTEIN-TYROSINE-PHOSPHATASE; JANUS KINASE/SIGNAL TRANSDUCER; JAK-STAT PATHWAY; SEX-DETERMINATION; GENE-EXPRESSION; STEM-CELLS; SIGNALING COMPONENTS; FEEDBACK INHIBITION; NEGATIVE REGULATION;
D O I：
10.1016/j.ymeth.2014.03.023
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) signaling pathway is one of a limited number of signaling cascades that is extensively utilized for many developmental and homeostatic functions. The JAK/STAT pathway is evolutionarily conserved from insects to mammals, with homologous transduction machinery in each. Yet the mammalian pathway is composed of multiple members for each family of proteins, while flies have only a single homologue of most pathway components. This simplicity and the abundance of genetic, biochemical, and developmental tools make Drosophila an attractive model to investigate this important signaling pathway. This review provides a basic description of the Drosophila JAK/STAT cascade and summarizes currently available reagents and tools to study and manipulate the pathway. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：160 / 172
页数：13
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