ESX/type VII secretion systems and their role in host-pathogen interaction

被引：192

作者：

Simeone, Roxane ^{[1
]}

Bottai, Daria ^{[1
,2
]}

Brosch, Roland ^{[1
]}

机构：

[1] Inst Pasteur, UP Pathogenom Mycobacterienne Integree, F-75724 Paris, France

[2] Univ Pisa, Dipartimento Patol Sperimentale, Pisa, Italy

来源：

CURRENT OPINION IN MICROBIOLOGY | 2009年 / 12卷 / 01期

关键词：

T-CELL ANTIGEN; MYCOBACTERIUM-TUBERCULOSIS; COMPLEX-FORMATION; ESAT-6; SECRETION; CALMETTE-GUERIN; VIRULENCE; RD1; EXPRESSION; MARINUM; PROTEIN;

D O I：

10.1016/j.mib.2008.11.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The ESX-1 system is responsible for the secretion of the prototypic ESX proteins, namely the 6 kDa early secreted antigenic target (ESAT-6) and the 10 kDa culture filtrate protein (UP-10). These two proteins, which form a 1:1 heterodimeric complex, are among the most important proteins of Mycobacterium tuberculosis involved in host-pathogen interaction. They induce a strong T cell mediated immune response, are apparently involved in membrane and/or host-cell lysis and represent key virulence factors. There are four other paralogous ESX systems in M. tuberculosis, some of which are essential for in vitro growth. ESX systems also exist in many other actinobacteria and Gram-positive bacteria, and have recently been suggested to be named type VII secretion systems.

引用

页码：4 / 10

页数：7

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