Microglia: Friends or Foes in Glaucoma? A Developmental Perspective

被引：12

作者：

Ahmad, Iqbal ^{[1
]}

Subramani, Murali ^{[1
]}

机构：

[1] Univ Nebraska Med Ctr, Dept Ophthalmol & Visual Sci, Omaha 68198, NE USA

来源：

STEM CELLS TRANSLATIONAL MEDICINE | 2022年 / 11卷 / 12期

关键词：

microglia; retinal ganglion cell; neurogenesis; degeneration; glaucoma; RETINAL GANGLION-CELL; MOUSE MODEL; DEATH; COMPLEMENT; FRACTALKINE; NEURONS; DIFFERENTIATION; ACTIVATION; DEFICITS; NEUROTOXICITY;

D O I：

10.1093/stcltm/szac077

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Glaucoma is the most prevalent form of optic neuropathy where a progressive degeneration of retinal ganglion cells (RGCs) leads to irreversible loss of vision. The mechanism underlying glaucomatous degeneration remains poorly understood. However, evidence suggests that microglia, which regulate RGC numbers and synaptic integrity during development and provide homeostatic support in adults, may contribute to the disease process. Hence, microglia represent a valid cellular target for therapeutic approaches in glaucoma. Here, we provide an overview of the role of microglia in RGC development and degeneration in the backdrop of neurogenesis and neurodegeneration in the central nervous system and discuss how pathological recapitulation of microglia-mediated developmental mechanisms may help initiate or exacerbate glaucomatous degeneration.

引用

页码：1210 / 1218

页数：9

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