Two new Daphniphyllum alkaloids from Daphniphyllum macropodum Miq.

被引：5
作者：
Li, Zhen-Yu [1 ]
Xu, Hong-Gui [2 ]
Zhao, Zhong-Zhen [2 ]
Guo, Yue-Wei [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China
[2] Hong Kong Baptist Univ, Sch Chinese Med, Kowloon, Hong Kong, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2009年 / 11卷 / 02期
关键词：
Daphniphyllum macropodum Miq; alkaloids; cytotoxicity; SKELETONS; CALYCINUM; CASCADE;
D O I：
10.1080/10286020802618837
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new Daphniphyllum alkaloids, 4,21-deacetyl-deoxyyuzurimine (1) and macropodumine L (2), together with the two known related alkaloids, have been isolated from the bark of Daphniphyllum macropodum Miq. The structures of the new compounds were elucidated on the basis of the detailed analysis of spectroscopic data, chemical method, and by comparison of the spectroscopic data with those of known compounds. Compounds 2 and 4 exhibited weak cytotoxicity against human carcinoma cell lines SMMC-7721 and HO-8910.
引用
收藏
页码：153 / 158
页数：6
相关论文
共 19 条
  • [1] *ADM BUR TRAD CHIN, 1998, CHIN MAT MED ZHONGH, V4, P865
  • [2] Isolation, X-ray crystallography, and computational studies of calydaphninone, a new alkaloid from Daphniphyllum calycillum
    Di, Ying-Tong
    He, Hong-Ping
    Wang, Yun-Song
    Li, Liang-Bo
    Lu, Yang
    Gong, Jian-Bo
    Fang, Xin
    Kong, Ning-Chuan
    Li, Shun-Lin
    Zhu, Hua-Jie
    Hao, Xiao-Jiang
    [J]. ORGANIC LETTERS, 2007, 9 (07) : 1355 - 1358
  • [3] Novel alkaloids, paxdaphnines A and B with unprecedented skeletons from the seeds of Daphniphyllum paxianum
    Fan, Cheng-Qi
    Yin, Sheng
    Xue, Jun-Juan
    Yue, Jian-Min
    [J]. TETRAHEDRON, 2007, 63 (01) : 115 - 119
  • [4] Nature knows best: An amazing reaction cascade is uncovered by design and discovery
    Heathcock, CH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) : 14323 - 14327
  • [5] DAPHNIPHYLLUM ALKALOIDS .3.
    IRIKAWA, H
    YAMAMURA, S
    HIRATA, Y
    [J]. TETRAHEDRON, 1972, 28 (14) : 3727 - &
  • [6] Kobayashi Jun'ichi, 2003, Alkaloids Chem Biol, V60, P165
  • [7] Further Daphniphyllum alkaloids from the bark of daphniphyllum macropodum Miq
    Li Zhen-Yu
    Chen Ping
    Xu Hong-Gui
    Peng Shu-Ying
    Yang Yi-Ming
    Zhao Zhong-Zhen
    Guo Yue-Wei
    [J]. CHINESE JOURNAL OF CHEMISTRY, 2008, 26 (02) : 348 - 352
  • [8] Further Daphniphyllum alkaloids from the leaves of Daphniphyllum macropodum MIQ
    Li, Zhen-Yu
    Chen, Ping
    Xu, Hong-Gui
    Peng, Shu-Ying
    Yang, Yi-Ming
    Zhao, Zhong-Zhen
    Guo, Yue-Wei
    [J]. HELVETICA CHIMICA ACTA, 2007, 90 (07) : 1353 - 1359
  • [9] Macropodumines D and E, two new alkaloids with unusual skeletons from Daphniphyllum macropodum Miq
    Li, Zhen-Yu
    Chen, Ping
    Xu, Hong-Gui
    Yang, Yi-Ming
    Peng, Shu-Ying
    Zhao, Zhong-Zhen
    Guo, Yue-Wei
    [J]. ORGANIC LETTERS, 2007, 9 (03) : 477 - 480
  • [10] Calyciphyllines A and B, two novel hexacyclic alkaloids from Daphniphyllum calycinum
    Morita, H
    Kobayashi, J
    [J]. ORGANIC LETTERS, 2003, 5 (16) : 2895 - 2898
12