Association of Genetic polymorphism of PPARγ-2, ACE, MTHFR, FABP-2 and FTO genes in risk prediction of type 2 diabetes mellitus

被引：41

作者：

Abbas, Shania ^{[1
]}

Raza, Syed Tasleem ^{[1
]}

Ahmed, Faisal ^{[1
]}

Ahmad, Absar ^{[1
]}

Rizvi, Saliha ^{[1
]}

Mahdi, Farzana ^{[1
]}

机构：

[1] Eras Lucknow Med Coll & Hosp, Dept Biochem, Mol Biol Lab, Lucknow 226003, Uttar Pradesh, India

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2013年 / 20卷

关键词：

Genome sequencing; Single nucleotide polymorphism; Genetic polymorphism; Peroxisome proliferator-activated receptor gamma; Angiotensin converting enzyme; Methylene tetrahydrofolate reductase; Fatty acid binding protein-2; Fat mass and obesity associated gene; Type 2 diabetes mellitus; FATTY-ACID-BINDING; POSTCHALLENGE INSULIN LEVELS; ACTIVATED RECEPTOR-GAMMA; BODY-MASS INDEX; PROTEIN-2; GENE; PPAR-GAMMA; CODON-54; POLYMORPHISM; ALA54THR POLYMORPHISM; I/D POLYMORPHISM; INSERTION/DELETION POLYMORPHISM;

D O I：

10.1186/1423-0127-20-80

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Type 2 diabetes mellitus (T2DM) is a non-autoimmune, complex, heterogeneous and polygenic metabolic disease condition characterized by persistent elevated blood glucose levels (hyperglycemia). India as said to be the diabetic capital of the world is likely to experience the largest increase in T2DM and a greater number of diabetic individuals in the world by the year 2030. Identification of specific genetic variations in a particular ethnic group has a critical role in understanding the risk of developing T2DM in a much efficient way in future. These genetic variations include numerous types of polymorphisms among which single nucleotide polymorphisms (SNPs) is the most frequent. SNPs are basically located within the regulatory elements of several gene sequences. There are scores of genes interacting with various environmental factors affecting various pathways and sometimes even the whole signalling network that cause diseases like T2DM. This review discusses the biomarkers for early risk prediction of T2DM. Such predictions could be used in order to understand the pathogenesis of T2DM and to better diagnostics, treatment, and eventually prevention.

引用

页数：8

共 101 条

[51] Variations in the FTO gene are associated with severe obesity in the Japanese [J].

Hotta, Kikuko ;

Nakata, Yoshio ;

Matsuo, Tomoaki ;

Kamohara, Seika ;

Kotani, Kazuaki ;

Komatsu, Ryoya ;

Itoh, Naoto ;

Mineo, Ikuo ;

Wada, Jun ;

Masuzaki, Hiroaki ;

Yoneda, Masato ;

Nakajima, Atsushi ;

Miyazaki, Shigeru ;

Tokunaga, Katsuto ;

Kawamoto, Manabu ;

Funahashi, Tohru ;

Hamaguchi, Kazuyuki ;

Yamada, Kentaro ;

Hanafusa, Toshiaki ;

Oikawa, Shinichi ;

Yoshimatsu, Hironobu ;

Nakao, Kazuwa ;

Sakata, Toshiie ;

Matsuzawa, Yuji ;

Tanaka, Kiyoji ;

Kamatani, Naoyuki ;

Nakamura, Yusuke .

JOURNAL OF HUMAN GENETICS, 2008, 53 (06) :546-553

[52] Increased frequency of angiotensin-converting enzyme DD genotype in patients with type 2 diabetes in Taiwan [J].

Hsieh, MC ;

Lin, SR ;

Hsieh, TJ ;

Hsu, CH ;

Chen, HC ;

Shin, SJ ;

Tsai, JH .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2000, 15 (07) :1008-1013

[53] Codon 54 polymorphism of the fatty acid binding protein gene and insulin resistance in the Japanese population [J].

Ito, K ;

Nakatani, K ;

Fujii, M ;

Katsuki, A ;

Tsuchihashi, K ;

Murata, K ;

Goto, H ;

Yano, Y ;

Gabazza, EC ;

Sumida, Y ;

Adachi, Y .

DIABETIC MEDICINE, 1999, 16 (02) :119-124

[54]

Jayapalan Jaime J, 2010, Indian J Hum Genet, V16, P78, DOI 10.4103/0971-6866.69351

[55]

Jia-Zhong S, 2009, INDIA, V57, P589

[56] Codon 54 polymorphism of the fatty acid binding protein 2 gene is associated with increased fat oxidation and hyperinsulinemia, but not with intestinal fatty acid absorption in Korean men [J].

Kim, CH ;

Yun, SK ;

Byun, DW ;

Yoo, MH ;

Lee, KU ;

Suh, KI .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2001, 50 (04) :473-476

[57]

Ksiazek P, 2004, MED SCI MONITOR, V10, pBR47

[58]

Kumar Ajay, 2005, International Journal of Human Genetics, V5, P279

[59] Comparison of the acute response to meals enriched with cis- or trans-fatty acids on glucose and lipids in overweight individuals with differing FABP2 genotypes [J].

Lefevre, M ;

Lovejoy, JC ;

Smith, SR ;

DeLany, JP ;

Champagne, C ;

Most, MM ;

Denkins, Y ;

de Jonge, L ;

Rood, J ;

Bray, GA .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2005, 54 (12) :1652-1658

[60] Variants of the insulin receptor substrate-1 and fatty acid binding protein 2 genes and the risk of type 2 diabetes, obesity, and hyperinsulinemia in African-Americans - The Atherosclerosis Risk in Communities Study [J].

Lei, HH ;

Coresh, J ;

Shuldiner, AR ;

Boerwinkle, E ;

Brancati, FL .

DIABETES, 1999, 48 (09) :1868-1872

← 1 2 3 4 5 6 7 8 9 10 →