Importance of Detecting Multidrug Resistance Proteins in Acute Leukemia Prognosis and Therapy

被引：29
|
作者：
Rabello de Moraes, Ana Carolina [1 ]
Maranho, Caroline Klein [2 ]
Rauber, Gabriela Schneider [1 ]
Santos-Silva, Maria Claudia [1 ,2 ]
机构：
[1] Univ Fed Santa Catarina, Programa Posgrad Farm, BR-88040900 Florianopolis, SC, Brazil
[2] Univ Fed Santa Catarina, Dept Anal Clin, BR-88040900 Florianopolis, SC, Brazil
来源：
JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2013年 / 27卷 / 01期
关键词：
multidrug resistance; ABCB1; ABCC1; LRP; acute leukemia; ACUTE MYELOID-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; P-GLYCOPROTEIN EXPRESSION; MAJOR VAULT PROTEIN; GAMMA-GLUTAMYLCYSTEINE SYNTHETASE; MDR1; GENE-EXPRESSION; CELL LUNG-CANCER; MRP/GS-X PUMP; DRUG-RESISTANCE; MESSENGER-RNA;
D O I：
10.1002/jcla.21563
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Multidrug resistance (MDR) is a multifactorial phenomenon and the role of these proteins in generating the MDR phenotype is controversial. With this in mind, this review compiled the current data on the role of ABCB1, ABCC1, and LRP proteins in the prognosis of hematologic neoplasms and their influence on the choice of therapy. Literature showed that the detection of these proteins, mainly ABCB1, is important in the AL prognosis. However, there is controversy regarding the methodology used for their detection. In summary, the expression and activity profiles of ABCB1, ABCC1, and LRP, proteins capable of promoting the efflux of a variety of chemotherapeutic agents from the cell cytoplasm represent one of the greatest causes of failure in AL treatment. J. Clin. Lab. Anal. 27:62-71, 2013. (c) 2012 Wiley Periodicals, Inc.
引用
收藏
页码：62 / 71
页数：10
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