One-step stereocontrolled synthesis of α-anomeric carboxylic acid esters from unprotected glycosyl donors:: A water-soluble aspirin pro-drug analogue

被引：0

作者：

Hanessian, S ^{[1
]}

Mascitti, V ^{[1
]}

Lu, PP ^{[1
]}

Ishida, H ^{[1
]}

机构：

[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada

来源：

SYNTHESIS-STUTTGART | 2002年 / 14期

关键词：

carbohydrates; aspirin; pro-drugs; esters; stereoselectivity;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of 2-(3-methoxypyridyl) beta-D-gluco- and D-galactopyranosides with various carboxylic acids affords the corresponding alpha-1-esters in high yields. Aspirin can be solubilized in water as the alpha-D-galactopyranosyl ester.

引用

页码：1959 / 1968

页数：10