Gene expression of leucine-rich alpha-2 glycoprotein in the polypoid lesion of inflammatory colorectal polyps in miniature dachshunds

被引：4

作者：

Ohta, Hiroshi ^{[1
]}

Tamura, Yu ^{[1
,4
]}

Yokoyama, Nozomu ^{[2
]}

Nagata, Noriyuki ^{[1
]}

Osuga, Tatsuyuki ^{[2
]}

Sasaki, Noboru ^{[1
]}

Kagawa, Yumiko ^{[3
]}

Morishita, Keitaro ^{[2
]}

Takiguchi, Mitsuyoshi ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Vet Med, Lab Vet Internal Med, Kita Ku, N18 W9, Sapporo, Hokkaido 0600818, Japan

[2] Hokkaido Univ, Vet Teaching Hosp, Grad Sch Vet Med, Kita Ku, N18 W9, Sapporo, Hokkaido 0600818, Japan

[3] NORTH LAB, Shiroishi Ku, Hondori 2 Chome,Kita8-35, Sapporo, Hokkaido 0030027, Japan

[4] Azabu Univ, Vet Teaching Hosp, Sagamihara, Kanagawa 2525201, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2020年 / 82卷 / 10期

关键词：

inflammatory colorectal polyp; inflammatory cytokine; leucine-rich alpha-2 glycoprotein; miniature dachshund; DISEASE-ACTIVITY BIOMARKER; ALPHA-2-GLYCOPROTEIN; MUCOSA;

D O I：

10.1292/jvms.20-0242

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Inflammatory colorectal polyps (ICRPs) in miniature dachshunds (MDs) are speculated to be a breed-specific inflammatory bowel disease (IBD). Leucine-rich alpha-2 glycoprotein (LRG) has been identified as a novel biomarker of human IBD. The aim of this study was to examine LRG gene expression in the polypoid lesions of ICRPs. Polypoid lesion specimens were collected from 24 MDs with ICRPs. Nonpolypoid colonic mucosa was collected from 18 MDs with ICRPs and 10 controls. The gene expression of LRG, interleukin (IL)-1 beta, IL-6, tumor necrosis factor-alpha, and IL-22 was examined. The expression of LRG gene was significantly increased in the polypoid lesions of ICRPs and correlated with that of the four cytokines. In conclusion, the LRG gene was expressed within the polypoid lesions of ICRPs and might be associated with local cytokine expression.

引用

页码：1445 / 1449

页数：5