Striatal morphology and neurocognitive dysfunction in Huntington disease: The IMAGE-HD study

被引：7

作者：

Wilkes, Fiona A. ^{[1
]}

Abaryan, Zvart ^{[2
]}

Ching, Chris R. K. ^{[2
]}

Gutman, Boris A. ^{[2
,3
]}

Madsen, Sarah K. ^{[2
]}

Walterfang, Mark ^{[4
,5
,6
,7
]}

Velakoulis, Dennis ^{[4
,5
,6
]}

Stout, Julie C. ^{[8
,9
]}

Chua, Phyllis ^{[10
]}

Egang, Gary F. ^{[8
,9
,11
]}

Thompson, Paul M. ^{[10
,12
,13
,14
,15
,16
,17
]}

Looi, Jeffrey C. L. ^{[1
,4
,5
]}

Georgiou-Karistianisg, Nellie ^{[8
,9
]}

机构：

[1] Australian Natl Univ, Med Sch, Canberra Hosp, Acad Unit Psychiat & Addict Med, Yamba Dr, Garran, ACT 2605, Australia

[2] Univ Southern Calif, Keck Sch Med, Stevens Inst Neuroimaging & Informat, Imaging Genet Ctr,Dept Neurol, 4676 Admiralty Way,Ste 200,Hlth Sci Campus, Marina Del Rey, CA 90292 USA

[3] IIT, Dept Biomed Engn, 3255 South Dearborn St,Wishnick Hall,Suite 314, Chicago, IL 60616 USA

[4] Royal Melbourne Hosp, Melbourne Neuropsychiat Ctr, Level 3 Alan Gilbert Bldg,161 Barry St, Calton, Vic 3053, Australia

[5] Univ Melbourne, Level 3 Alan Gilbert Bldg,161 Barry St, Calton, Vic 3053, Australia

[6] Royal Melbourne Hosp, Neuropsychiat Unit, Level 2,John Cade Bldg, Calton, Vic 3050, Australia

[7] Florey Inst Neurosci & Mental Hlth, 30 Royal Parade, Parkville, Vic 3052, Australia

[8] Monash Univ, Sch Psychol Sci, 18 Innovat Walk,Clayton Campus,Wellington Rd, Clayton, Vic 3800, Australia

[9] Monash Univ, Monash Inst Cognit & Clin Neurosci, 18 Innovat Walk,Clayton Campus,Wellington Rd, Melbourne, Vic 3800, Australia

[10] Monash Univ, Dept Psychiat, Sch Clin Sci, Monash Med Ctr, Block P,Level 3 246 Clayton Rd, Clayton, Vic 3168, Australia

[11] Monash Univ, Monash Biomed Imaging, 770 Blackburn Roacl,Bldg 220, Clayton, Vic 3800, Australia

[12] Univ Southern Calif, Dept Neurol, Marina Del Rey, CA USA

[13] Univ Southern Calif, Dept Psychiat, Marina Del Rey, CA USA

[14] Univ Southern Calif, Dept Radiol, Marina Del Rey, CA USA

[15] Univ Southern Calif, Dept Engn, Marina Del Rey, CA USA

[16] Univ Southern Calif, Dept Pediat, Marina Del Rey, CA USA

[17] Univ Southern Calif, Dept Ophthalmol, Marina Del Rey, CA USA

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2019年 / 291卷

基金：

英国医学研究理事会;

关键词：

Neostriatum; Endophenotype; Biomarker Huntington disease; BASAL GANGLIA; PREMANIFEST; INTERFERENCE; RELIABILITY; PSYCHIATRY; NUCLEUS; ATROPHY; SCALE;

D O I：

10.1016/j.pscychresns.2019.07.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We aimed to investigate the relationship between striatal morphology in Huntington disease (HD) and measures of motor and cognitive dysfunction. MRI scans, from the IMAGE-HD study, were obtained from 36 individuals with pre-symptomatic HD (pre-HD), 37 with early symptomatic HD (symp-HD), and 36 healthy matched controls. The neostriatum was manually segmented and a surface-based parametric mapping protocol derived two pointwise shape measures: thickness and surface dilation ratio. Significant shape differences were detected between all groups. Negative associations were detected between lower thickness and surface area shape measure and CAG repeats, disease burden score, and UHDRS total motor score. In symp-HD, UPSIT scores were correlated with higher thickness in left caudate tail and surface dilation ratio in left posterior putamen; Stroop scores were positively correlated with the thickness of left putamen head and body. Self-paced tapping (slow) was correlated with higher thickness and surface dilation ratio in the right caudate in symp-HD and with bilateral putamen in pre-HD. Self-paced tapping (fast) was correlated with higher surface dilation ratio in the right anterior putamen in symp-HD. Shape changes correlated with functional measures subserved by corticostriatal circuits, suggesting that the neostriatum is a potentially useful structural basis for characterisation of endophenotypes of HD.

引用

页码：1 / 8

页数：8

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[11] Multimodal imaging biomarkers in premanifest and early Huntington's disease: 30-month IMAGE-HD data [J].