The CD2-subset of the Ig superfamily of cell surface molecules: receptor-ligand pairs expressed by NK cells and other immune cells

被引:117
作者
Tangye, SG
Phillips, JH
Lanier, LL
机构
[1] DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol, Palo Alto, CA 94304 USA
[2] Univ Sydney, Centenary Inst Canc Med & Cell Biol, Immune Regulat Grp, Sydney, NSW 2042, Australia
关键词
CD2; NK cells; SAP; T cells; X-linked lymphoproliferative syndrome;
D O I
10.1006/smim.2000.0217
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The CD2-subset of the immunoglobulin superfamily of cell surface receptors is an emerging family of proteins involved in cellular activation. Members of this family are CD2, CD48, CD58, CD84, signaling lymphocytic activation molecule (SLAM), 2B4 and Ly-9. These proteins are expressed on different leukocyte populations and the receptors of this family, specifically CD2, 2B4 and SLAM, contribute to the activation of T cells and natural killer cells. 2B4 and SLAM associate with a protein termed SLAM-associated protein that is the genetic defect in the immunodeficiency X-linked lymphoproliferative syndrome. Impaired signaling via these receptors may contribute to this often-fatal immunodeficiency.
引用
收藏
页码:149 / 157
页数:9
相关论文
共 78 条
[31]   CD48 IS A COUNTER-RECEPTOR FOR MOUSE CD2 AND IS INVOLVED IN T-CELL ACTIVATION [J].
KATO, K ;
KOYANAGI, M ;
OKADA, H ;
TAKANASHI, T ;
WONG, YW ;
WILLIAMS, AF ;
OKUMURA, K ;
YAGITA, H .
JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (05) :1241-1249
[32]   DEVELOPMENT AND FUNCTION OF T-CELLS IN MICE WITH A DISRUPTED CD2 GENE [J].
KILLEEN, N ;
STUART, SG ;
LITTMAN, DR .
EMBO JOURNAL, 1992, 11 (12) :4329-4336
[33]   PHYSICAL AND GENETIC-LINKAGE OF THE GENES ENCODING LY-9 AND CD48 ON MOUSE AND HUMAN-CHROMOSOMES-1 [J].
KINGSMORE, SF ;
SOURYAL, CA ;
WATSON, ML ;
PATEL, DD ;
SELDIN, MF .
IMMUNOGENETICS, 1995, 42 (01) :59-62
[34]  
Kishimoto T, 1997, LEUCOCYTE TYPING
[35]  
Kubota K, 1999, IMMUNOLOGY, V96, P491
[36]   Arousal and inhibition of human NK cells [J].
Lanier, LL ;
Corliss, B ;
Phillips, JH .
IMMUNOLOGICAL REVIEWS, 1997, 155 :145-154
[37]   NK cell receptors [J].
Lanier, LL .
ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :359-393
[38]  
Latchman Y, 1998, J IMMUNOL, V161, P5809
[39]   Molecular basis of T cell inactivation by CTLA-4 [J].
Lee, KM ;
Chuang, E ;
Griffin, M ;
Khattri, R ;
Hong, DK ;
Zhang, WG ;
Straus, D ;
Samelson, LE ;
Thompson, CB ;
Bluestone, JA .
SCIENCE, 1998, 282 (5397) :2263-2266
[40]   Association of p59fyn with the T lymphocyte costimulatory receptor CD2 -: Binding of the Fyn Src homology (SH) 3 domain is regulated by the Fyn SH2 domain [J].
Lin, HM ;
Hutchcroft, JE ;
Andoniou, CE ;
Kamoun, M ;
Band, H ;
Bierer, BE .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (31) :19914-19921