The relationship between cadmium exposure and renal volume in inhabitants of a cadmium-polluted area of Japan

被引:15
作者
Sun, Xian Liang [1 ,2 ]
Kido, Teruhiko [3 ]
Nakagawa, Hideaki [4 ]
Nishijo, Muneko [5 ]
Sakurai, Masaru [6 ]
Ishizaki, Masao [6 ]
Morikawa, Yuko [7 ]
Okamoto, Rie [3 ]
Ichimori, Akie [3 ]
Ohno, Naoki [3 ]
Kobayashi, Satoshi [3 ]
Miyati, Toshiaki [3 ]
Nogawa, Kazuhiro [8 ]
Suwazono, Yasushi [8 ]
机构
[1] Jiaxing Univ, Sch Med, 118 Jiahang Rd, Jiaxing 314001, Peoples R China
[2] Natl Inst Environm Studies, Ctr Hlth & Environm Risk Res, Tsukuba, Ibaraki, Japan
[3] Kanazawa Univ, Sch Hlth Sci, Kanazawa, Ishikawa 9200942, Japan
[4] Kanazawa Med Univ, Inst Med Sci, Uchinada, Ishikawa 9200293, Japan
[5] Kanazawa Med Univ, Dept Publ Hlth, Uchinada, Ishikawa 9200293, Japan
[6] Kanazawa Med Univ, Dept Social & Environm Med, Uchinada, Ishikawa 9200293, Japan
[7] Kanazawa Med Univ, Sch Nursing, Dept Med, Uchinada, Ishikawa 9200293, Japan
[8] Chiba Univ, Grad Sch Med, Dept Occupat & Environm Med, Chiba 2608670, Japan
关键词
Urinary cadmium (U-Cd); Urinary N-acetyl-beta-d-glucosaminidase (NAG); Serum alkaline phosphatase (Al-P); Magnetic resonance imaging (MRI); Aging; JINZU RIVER WATER; BETA-D-GLUCOSAMINIDASE; KIDNEY-FUNCTION; BLOOD-PRESSURE; DYSFUNCTION; URINE;
D O I
10.1007/s11356-020-12278-7
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
This follow-up study was conducted over 30 years in a cadmium-polluted area of Japan. Urinary cadmium (U-Cd) concentration decreased by nearly half from 1986 to 2008 in men and women. However, it increased from 2008 to 2014 and maintained similar levels in 2016. Because renal atrophy may induce an increase in U-Cd, kidney volumes were determined using magnetic resonance imaging (MRI) scans in 2018. Based on the MRI results, we divided the participants into two groups, namely the normal group (n = 6, three men and three women) and the lesion group (n = 6, three men and three women). The level of urinary N-acetyl-beta-d-glucosaminidase/creatinine (U-NAG/Cr) in the lesion group was significantly higher than in the normal group. The level of serum alkaline phosphatase (Al-P) was positively associated with U-Cd. Age and renal cortex volumes showed significantly negative associations. However, U-Cd and renal cortex and kidney volumes showed no significant associations. These results suggest that U-NAG and serum Al-P were sensitive biomarkers to reflect renal tubular dysfunction and bone damage caused by cadmium poisoning. Individuals chronically exposed to Cd should be observed carefully, due to the increased effect of aging on renal cortex volumes.
引用
收藏
页码:22372 / 22379
页数:8
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