Schisanwilsonins A-G and related anti-HBV lignans from the fruits of Schisandra wilsoniana

被引：42

作者：

Ma, Wen-Hui ^{[1
]}

Lu, Yan ^{[1
]}

Huang, Hai ^{[2
]}

Zhou, Pei ^{[2
]}

Chen, Dao-Feng ^{[1
]}

机构：

[1] Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China

[2] Fudan Univ, Sch Pharm, Dept Biosynthet Med Chem, Shanghai 201203, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 17期

基金：

中国国家自然科学基金;

关键词：

Schisandra wilsoniana; Schisanwilsonin; Anti-HBV; Lignan; C-18 DIBENZOCYCLOOCTADIENE LIGNANS; SCHIZANDRA-CHINENSIS BAILL; KADSURA-HETEROCLITA; CONSTITUENTS; HOMOLIGNANS; ARISANENSIS; HEPATITIS; INTERIOR; STEMS; HBEAG;

D O I：

10.1016/j.bmcl.2009.07.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven new dibenzocyclooctane lignans, schisanwilsonins A-G (1-7), were isolated from the fruits of Schisandra wilsoniana, together with five known lignans (8-12). The structures of these new compounds were elucidated by spectroscopic methods including 2D-NMR techniques. The 12 lignans were tested for anti-hepatitis B virus (HBV) activity in vitro. Schisanwilsonin D ( 4), schisantherin C (9), deoxyschizandrin (10) and (+)-gomisin K-3 (11) showed anti-HBV activity. 9 exhibited the most potent anti-HBV activity with potency against HBsAg and HBeAg secretion by 59.7% and 34.7%, respectively, at 50 mu g/mL. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4958 / 4962

页数：5

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