Ribosome-associated protein quality control

被引：315
作者：
Brandman, Onn [1 ]
Hegde, Ramanujan S. [2 ]
机构：
[1] Stanford Univ, Dept Biochem, Stanford, CA 94305 USA
[2] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2016年 / 23卷 / 01期
基金：
英国医学研究理事会; 美国国家卫生研究院;
关键词：
MESSENGER-RNA DECAY; DEPENDENT TRANSLATION ARREST; E3 UBIQUITIN LIGASE; CONTROL COMPLEX; COTRANSLATIONAL UBIQUITINATION; SUBUNIT DISSOCIATION; STRUCTURAL BASIS; NASCENT CHAINS; POLY(A) TAIL; DEGRADATION;
D O I：
10.1038/nsmb.3147
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Protein synthesis by the ribosome can fail for numerous reasons including faulty mRNA, insufficient availability of charged tRNAs and genetic errors. All organisms have evolved mechanisms to recognize stalled ribosomes and initiate pathways for recycling, quality control and stress signaling. Here we review the discovery and molecular dissection of the eukaryotic ribosome-associated quality-control pathway for degradation of nascent polypeptides arising from interrupted translation.
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页码：7 / 15
页数：9
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