The synthesis of peptides and proteins containing non-natural amino acids

被引：123
作者：
Hodgson, DRW [1 ]
Sanderson, JM [1 ]
机构：
[1] Univ Durham, Dept Chem, Durham DH1 3LE, England
来源：
CHEMICAL SOCIETY REVIEWS | 2004年 / 33卷 / 07期
关键词：
D O I：
10.1039/b312953p
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Methods for the incorporation of non-natural amino acids into proteins have advanced significantly over recent years and in this tutorial review we aim to give a general overview of the area. These techniques offer the possibility of modulating the structures and functions of proteins and thus permit the generation of novel designed systems for both biocatalytic and mechanistic studies. Four complementary approaches are discussed in detail along with examples of their application. The advantages and disadvantages of each technique are also discussed.
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收藏
页码：422 / 430
页数：9
相关论文
共 54 条
[11]   Synthesis of the protein cutting reagent iron (S)-1-(p-bromoacetamidobenzyl)ethylenediaminetetraacetate and conjugation to cysteine side chains [J].
Greiner, DP ;
Miyake, R ;
Moran, JK ;
Jones, AD ;
Negishi, T ;
Ishihama, A ;
Meares, CF .
BIOCONJUGATE CHEMISTRY, 1997, 8 (01) :44-48
[12]   T4 RNA LIGASE MEDIATED PREPARATION OF NOVEL CHEMICALLY MISACYLATED TRANSFER-RNA PHES [J].
HECKLER, TG ;
CHANG, LH ;
ZAMA, Y ;
NAKA, T ;
CHORGHADE, MS ;
HECHT, SM .
BIOCHEMISTRY, 1984, 23 (07) :1468-1473
[13]  
HERMANSON GT, 1996, BIOCONJUGATE TECHNIQ
[14]   Incorporation of nonnatural amino acids into proteins by using various four-base codons in an Escherichia coli in vitro translation system [J].
Hohsaka, T ;
Ashizuka, Y ;
Taira, H ;
Murakami, H ;
Sisido, M .
BIOCHEMISTRY, 2001, 40 (37) :11060-11064
[15]   Polyketide and non-ribosomal peptide synthases: Falling together by coming apart [J].
Hutchinson, CR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (06) :3010-3012
[16]   A DESIGNED PEPTIDE LIGASE FOR TOTAL SYNTHESIS OF RIBONUCLEASE-A WITH UNNATURAL CATALYTIC RESIDUES [J].
JACKSON, DY ;
BURNIER, J ;
QUAN, C ;
STANLEY, M ;
TOM, J ;
WELLS, JA .
SCIENCE, 1994, 266 (5183) :243-247
[17]   Toward understanding and tailoring the specificity of synthetically useful enzymes [J].
Jones, JB ;
Desantis, G .
ACCOUNTS OF CHEMICAL RESEARCH, 1999, 32 (02) :99-107
[18]  
Keating TA, 2001, CHEMBIOCHEM, V2, P99, DOI 10.1002/1439-7633(20010202)2:2<99::AID-CBIC99>3.3.CO
[19]  
2-V
[20]   Expanding the utility of proteases in synthesis: broadening the substrate acceptance in non-coded amide bond formation using chemically modified mutants of subtilisin [J].
Khumtaveeporn, K ;
Ullmann, A ;
Matsumoto, K ;
Davis, BG ;
Jones, JB .
TETRAHEDRON-ASYMMETRY, 2001, 12 (02) :249-261
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