Associations of Quadriceps Torque Properties with Muscle Size, Attenuation, and Intramuscular Adipose Tissue in Older Adults

被引:32
作者
Frank-Wilson, Andrew W. [1 ,2 ]
Chalhoub, Didier [1 ]
Figueiredo, Pedro [1 ,3 ]
Jonsson, Palmi V. [4 ,5 ]
Siggeirsdottir, Kristin [6 ]
Sigurdsson, Sigurdur [6 ]
Eiriksdottir, Gudny [6 ]
Guonason, Vilmundur [5 ,6 ]
Launer, Lenore [1 ]
Harris, Tamara B. [1 ]
机构
[1] NIA, Lab Epidemiol & Populat Sci, Bethesda, MD 20892 USA
[2] Univ Saskatchewan, Coll Kinesiol, Saskatoon, SK, Canada
[3] Univ Inst Maia, ISMAI, CIDESD, Res Ctr Sports Sci Hlth Sci & Human Dev, Porto, Portugal
[4] Landspitali Univ Hosp, Dept Geriatr, Reykjavik, Iceland
[5] Univ Iceland, Fac Med, Reykjavik, Iceland
[6] Iceland Heart Assoc Res Inst, Reykjavik, Iceland
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2018年 / 73卷 / 07期
基金
美国国家卫生研究院;
关键词
Power; Physical function; Fat; Knee extension; Rate of force development; COMPUTED-TOMOGRAPHY; SKELETAL-MUSCLE; BODY-COMPOSITION; HIP FRACTURE; STRENGTH; AGE; POWER; MYOSTEATOSIS; NONFALLERS; DENSITY;
D O I
10.1093/gerona/glx262
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: Atrophy and fatty infiltration of muscle with aging are associated with fractures and falls, however, their direct associations with muscle function are not well described. It was hypothesized that participants with lower quadriceps muscle attenuation, area, and greater intramuscular adipose tissue (IMAT) will exhibit slower rates of torque development (RTD) and lower peak knee extension torques. Methods: Data from 4,842 participants (2,041 men, 2,801 women) from the Age Gene/Environment Susceptibility Reykjavik Study (mean age 76 +/- 0.1 years) with complete thigh computed tomography and isometric knee testing. Regression models were adjusted for health, behavior, and comorbidities. Muscle attenuation was further adjusted for muscle area and IMAT; muscle area adjusted for IMAT and attenuation; and IMAT adjusted for muscle area and attenuation. Standardized betas (beta) indicate association effect sizes. Results: In the fully-adjusted models, attenuation (men beta = 0.06, 95% CI: 0.01, 0.11; women beta = 0.07, 95% CI: 0.03, 0.11) and muscle area (men beta = 0.13, 95% CI: 0.07, 0.19; women beta = 0.10, 95% CI: 0.06, 0.15) were associated with knee RTD. Attenuation (men beta = 0.12, 95% CI: 0.08, 0.16; women beta = 0.12, 95% CI: 0.09, 0.16) and muscle area (men beta = 0.38, 95% CI: 0.33, 0.43; women beta = 0.33, 95% CI: 0.29, 0.37) were associated with peak torque. Conclusions: These data suggest that muscle attenuation and area are independently associated with RTD and peak torque; and that area and attenuation demonstrate similar contributions to RTD.
引用
收藏
页码:931 / 938
页数:8
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