Influence of drying conditions on process properties and parameter identification for continuous fluidized bed spray agglomeration

Agglomeration is a particle formulation process in which at least two primary particles are combined to form a new one. The growth of agglomerates depends on interactions of particles covered with wet spots that generated by depositions of binder droplets. This work experimentally compares the influence of external feed rate and sprayed binder content on product properties and process stability with internal separation at different drying conditions. Due to the identification of parameters a populations balance model (PBM) is developed. The PBM includes the agglomeration kernel function, which characterizes the kinetics, i.e. the rate at which primary particles build agglomerates.