Optimizing vaccine design for cellular processing, MHC binding and TCR recognition

被引：81

作者：

Sette, A ^{[1
]}

Newman, M ^{[1
]}

Livingston, B ^{[1
]}

McKinney, D ^{[1
]}

Sidney, J ^{[1
]}

Ishioka, G ^{[1
]}

Tangri, S ^{[1
]}

Alexander, J ^{[1
]}

Fikes, J ^{[1
]}

Chestnut, R ^{[1
]}

机构：

[1] Epimmune Inc, San Diego, CA 92121 USA

来源：

TISSUE ANTIGENS | 2002年 / 59卷 / 06期

关键词：

cancer; epitope; evolution; heteroclitic; HLA; infectious diseases; polymorphism;

D O I：

10.1034/j.1399-0039.2002.590601.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this review we describe the methods and processes that our group have developed while aiming to test and design multiepitope vaccines for infectious diseases and cancer. Testing the performance of vaccines. composed of epitopes restricted by human leukocyte antigen (HLA) molecules is accomplished by in vitro antigenicity assays, as well as in vivo immunogenicity assays in HLA transgenics. The efficiency by which multiepitope vaccines are processed is optimized by spacer residues, which are designed to facilitate generation by natural processing of the various class I- and class II-restricted epitopes, Methods and strategies to test and San Diego, optimize HLA binding affinity, patient coverage from the vaccine construct, and TCR recognition of HLA/epitope complexes are also discussed.

引用

页码：443 / 451

页数：9

共 47 条

[1] Alexander J, 1997, J IMMUNOL, V159, P4753
[2] Sequence signals for generation of antigenic peptides by the proteasome: Implications for proteasomal cleavage mechanism
Altuvia, Y
Margalit, H
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2000, 295 (04) : 879 - 890
[3] A multivalent minigene vaccine, containing B-cell, cytotoxic T-lymphocyte, and T-h epitopes from several microbes, induces appropriate responses in vivo and confers protection against more than one pathogen
An, LL
Whitton, JL
[J]. JOURNAL OF VIROLOGY, 1997, 71 (03) : 2292 - 2302
[4] Das P, 2000, Rev Immunogenet, V2, P105
[5] IDENTIFICATION OF THE PEPTIDE BINDING MOTIF FOR HLA-B44, ONE OF THE MOST COMMON HLA-B ALLELES IN THE CAUCASIAN POPULATION
DIBRINO, M
PARKER, KC
MARGULIES, DH
SHILOACH, J
TURNER, RV
BIDDISON, WE
COLIGAN, JE
[J]. BIOCHEMISTRY, 1995, 34 (32) : 10130 - 10138
[6] Two complementary methods for predicting peptides binding major histocompatibility complex molecules
Gulukota, K
Sidney, J
Sette, A
DeLisi, C
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1997, 267 (05) : 1258 - 1267
[7] DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum:: immunogenicity in mice
Hanke, T
Schneider, J
Gilbert, SC
Hill, AVS
McMichael, A
[J]. VACCINE, 1998, 16 (04) : 426 - 435
[8] Effective induction of HIV-specific CTL by multi-epitope using gene gun in a combined vaccination regime
Hanke, T
Neumann, VC
Blanchard, TJ
Sweeney, P
Hill, AVS
Smith, GL
McMichael, A
[J]. VACCINE, 1999, 17 (06) : 589 - 596
[9] Ishioka GY, 1999, J IMMUNOL, V162, P3915
[10] KAWASHIMA I, 1999, CAN RES, V162, P1156

← 1 2 3 4 5 →