Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism

被引：266

作者：

Roh, Eun ^{[1
,2
]}

Song, Do Kyeong ^{[1
,3
]}

Kim, Min-Seon ^{[1
,3
]}

机构：

[1] Univ Ulsan, Coll Med, Appeptite Regulat Lab, Asan Inst Life Sci, Seoul 138736, South Korea

[2] Univ Ulsan, Coll Med, Dept Med, Seoul 138736, South Korea

[3] Asan Med Ctr, Div Endocrinol & Metab, Seoul, South Korea

来源：

EXPERIMENTAL AND MOLECULAR MEDICINE | 2016年 / 48卷

基金：

新加坡国家研究基金会;

关键词：

ACTIVATED PROTEIN-KINASE; BROWN ADIPOSE-TISSUE; CENTRAL-NERVOUS-SYSTEM; SENSITIVE K+ CHANNELS; VENTROMEDIAL HYPOTHALAMIC NUCLEUS; CONTROLLING FOOD-INTAKE; DIET-INDUCED OBESITY; COUNTERREGULATORY HORMONE RESPONSES; HEPATIC INSULIN-RESISTANCE; BODY-WEIGHT;

D O I：

10.1038/emm.2016.4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Accumulated evidence from genetic animal models suggests that the brain, particularly the hypothalamus, has a key role in the homeostatic regulation of energy and glucose metabolism. The brain integrates multiple metabolic inputs from the periphery through nutrients, gut-derived satiety signals and adiposity-related hormones. The brain modulates various aspects of metabolism, such as food intake, energy expenditure, insulin secretion, hepatic glucose production and glucose/fatty acid metabolism in adipose tissue and skeletal muscle. Highly coordinated interactions between the brain and peripheral metabolic organs are critical for the maintenance of energy and glucose homeostasis. Defective crosstalk between the brain and peripheral organs contributes to the development of obesity and type 2 diabetes. Here we comprehensively review the above topics, discussing the main findings related to the role of the brain in the homeostatic regulation of energy and glucose metabolism.

引用

页码：e216 / e216

页数：12

共 173 条

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