N6-methyladenosine as a biological and clinical determinant in colorectal cancer: progression and future direction

被引：43
作者：
Li, Jinming [1 ,2 ]
Liang, Lei [1 ,2 ]
Yang, Yongzhi [1 ,2 ]
Li, Xinxiang [1 ,2 ]
Ma, Yanlei [1 ,2 ]
机构：
[1] Fudan Univ, Dept Colorectal Surg, Shanghai Canc Ctr, 270 Dongan Rd, Shanghai 200032, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China
来源：
THERANOSTICS | 2021年 / 11卷 / 06期
基金：
中国国家自然科学基金;
关键词：
colorectal cancer; m(6)A; RNA modification; cancer progression; cancer treatment; MESSENGER-RNA METHYLATION; GUT MICROBIOTA; NUCLEAR-RNA; M(6)A METHYLTRANSFERASE; PROGNOSTIC VALUE; OBESITY; M6A; RISK; GENE; DEMETHYLASE;
D O I：
10.7150/thno.52366
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Colorectal cancer (CRC) is one of the most prevalent cancers and one of the leading causes of cancer death. Recent studies have provided evidence that N-6-methyladenosine (m(6)A), the most abundant RNA modifications in eukaryote, performs many functions in RNA metabolism including translation, splicing, storage, trafficking and degradation. Aberrant regulation of m(6)A modification in mRNAs and noncoding RNAs found in CRC tissues is crucial for cancer formation, progression, invasion and metastasis. Further, m(6)A regulators and m(6)A-related RNAs may become promising biomarkers, prognosis predictors as well as therapeutic targets. Here, we review the biological and clinical roles of m(6)A modification in CRC, and discuss the potential of m(6)A in clinical translation.
引用
收藏
页码：2581 / 2593
页数：13
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