Cationic Porphyrins and Analogues as New DNA Topoisomerase I and II Inhibitors

被引：25

作者：

Shuai, Li ^{[1
]}

Wang, Shaoru ^{[1
]}

Zhang, Lixia ^{[1
]}

Fu, Boqiao ^{[1
]}

Zhou, Xiang ^{[1
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2009年 / 6卷 / 06期

关键词：

BINDING; PHTHALOCYANINE; TELOMERASE; MECHANISM;

D O I：

10.1002/cbdv.200800083

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of cationic porphyrins. and analogues such as cationic corroles and phthalocyanines were found to have biological activities towards topoisomerases I and II in vitro. Cationic porphyrins and phthalocyanines do not induce Topo I-DNA covalent complexes but inhibit topoisomerase I by direct binding to DNA, which limits topoisomerase I access to the DNA substrate. The lowest concentration where in inhibition effect is clearly visible of some derivatives is between 0.1 and 0.6 mu M. Furthermore, some complexes Were found 10 inhibit the activity of the topoisomerase II

引用

页码：827 / 837

页数：11

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