Risk Factors and Viruses Associated With Hospitalization Due to Lower Respiratory Tract Infections in Canadian Inuit Children A Case-Control Study

被引：62

作者：

Banerji, Anna ^{[1
,2
]}

Greenberg, David ^{[3
]}

White, Laura Forsberg ^{[4
]}

Macdonald, W. Alexander ^{[5
]}

Saxton, Audrey ^{[6
]}

Thomas, Eva ^{[7
]}

Sage, Douglas ^{[5
]}

Mamdani, Muhammad ^{[8
]}

Lanctot, Krista L. ^{[9
]}

Mahony, James B. ^{[10
]}

Dingle, Mia ^{[6
]}

Roberts, Ann ^{[5
]}

机构：

[1] Univ Toronto, St Michaels Hosp, Dept Pediat, Toronto, ON M5C 2T2, Canada

[2] Univ Toronto, St Michaels Hosp, Dalla Lana Sch Publ Hlth, Toronto, ON M5C 2T2, Canada

[3] Ben Gurion Univ Negev, Soroka Univ Med Ctr, IL-84105 Beer Sheva, Israel

[4] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

[5] Govt Nunavut, Hlth & Social Serv, Iqaluit, NU, Canada

[6] Baffin Reg Hosp, Iqaluit, NU, Canada

[7] British Columbia Childrens Hosp, Dept Pathol & Lab Med, Vancouver, BC V6H 3V4, Canada

[8] St Michaels Hosp, Li Ka Shing Knowledge Inst, AHRC, Toronto, ON M5B 1W8, Canada

[9] Univ Toronto, Sunnybrook Hlth Sci Ctr, MORE Res Grp, Toronto, ON M5C 2T2, Canada

[10] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2009年 / 28卷 / 08期

关键词：

Inuit; lower respiratory tract infections; crowding; smoking; rural; INVESTIGATORS COLLABORATIVE NETWORK; INFANT-DEATH-SYNDROME; NON-INDIAN CHILDREN; DISEASE; BRONCHIECTASIS; BRONCHIOLITIS; PROPHYLAXIS; MORBIDITY; ADMISSION; BORN;

D O I：

10.1097/INF.0b013e31819f1f89

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objectives: To examine risk factors for lower respiratory tract infections (LRTI) hospital admission in the Canadian Arctic. Methods: This was a case-control study during a 14-month period among children less than 2 years of age. Cases were admitted to the Baffin Regional Hospital in Iqaluit, Nunavut with LRTI. Controls were age matched and came from Iqaluit and 2 communities. Odds ratios (ORs) of hospital admission for LRTI were estimated through multivariate conditional logistic regression modeling for following risk factors: smoking in pregnancy, Inuit race, prematurity, adoption status, breast-feeding, overcrowding, and residing outside of Iqaluit. Viruses in nasophayngeal aspirates were sought at the time of each hospital admission. Results: There were 101 age-matched cases and controls. The following risk factors were significantly associated with an increased risk of admission for LRTI (adjusted OR): smoking in pregnancy (OR 4.0; 95% CI: 1.1-14.6), residence outside of Iqaluit (OR = 2.7; 95% CI: 1.0-7.2), full Inuit race (OR = 3.8; 95% CI: 1.1-12.8), and overcrowding (OR = 2.5, 95% CI: 1.1-6.1). Non-breast-fed children had a 3.6-fold risk of being admitted for LRTI (95% CI: 1.2-11.5) and non-breast-fed adopted children had a 4.4-fold increased risk (95% CI: 1.1-17.6) when compared with breast-fed, nonadopted children. Prematurity was not associated with an increased risk of admission. Viruses were identified in 88 (72.7%) of admissions, with respiratory syncytial virus being identified in the majority of admissions, 62 (51.2%). Multiple viruses were isolated in 19 (15.7%) admissions. Conclusions: Smoking during pregnancy, place of residence, Inuit race, lack of breast-feeding, and overcrowding were all independently associated with increased risk of hospital admission lot LRTI among Inuit children less than 2 years of age. Future research on the role of adoption and genetics on the health of Inuit children are required.

引用

页码：697 / 701

页数：5

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[3]

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