Ruthenium-catalyzed hydrovinylation of dienoates: Model studies directed toward the c10-c18 segment of ambruticin

被引：21

作者：

He, ZJ ^{[1
]}

Yi, CS ^{[1
]}

Donaldson, WA ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Milwaukee, WI 53201 USA

来源：

SYNLETT | 2004年 / 07期

关键词：

ruthenium catalysis; hydrovinylation; cross-metathesis;

D O I：

10.1055/s-2004-825605

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The ruthenium-catalyzed hydrovinylation of 2,4-dienoates 3 proceeds in a regioselective fashion to give 4-alkyl-2,5-dienoates 4 in good yields. Olefin cross-metathesis of a vinylcyclopropane with 4e demonstrates a synthetic route to the C10-C18 segment of ambruticin.

引用

页码：1312 / 1314

页数：3

共 29 条

[1]

Bösmann A, 2001, ANGEW CHEM INT EDIT, V40, P2697, DOI 10.1002/1521-3773(20010716)40:14<2697::AID-ANIE2697>3.0.CO

[2]

2-W

[3] INTERMEDIATES IN THE EPOXIDATION OF ALKENES BY CYTOCHROME-P-450 MODELS .2. USE OF THE TRANS-2,TRANS-3-DIPHENYLCYCLOPROPYL SUBSTITUENT IN A SEARCH FOR RADICAL INTERMEDIATES [J].