Interaction of halothane with alpha- and beta-adrenoceptor stimulations in rat myocardium

被引:40
作者
Hanouz, JL
Riou, B
Massias, L
Lecarpentier, Y
Coriat, P
机构
[1] UNIV PARIS 06,CHU PITIE SALPETRIERE,LAB ANESTHESIOL,DEPT ANESTHESIE REANIMAT,PARIS,FRANCE
[2] CHU COTE NACRE,DEPT ANESTHESIE REANIMAT,CAEN,FRANCE
[3] CHU BICHAT,LAB PHARMACOCINET & TOXICOL,PARIS,FRANCE
[4] ECOLE POLYTECH,INSERM U451,LOA,ENSTA,PALAISEAU,FRANCE
[5] UNIV PARIS SUD,HOP BICETRE,SERV PHYSIOL,F-94275 LE KREMLIN BICETR,FRANCE
关键词
anesthetics; volatile; halothane; heart; adrenoceptors; alpha; beta; papillary muscle; contractility; relaxation;
D O I
10.1097/00000542-199701000-00019
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background: Halothane induces negative inotropic and lusitropic effects in myocardium. It has been suggested that halothane potentiates beta-adrenoceptor stimulation. However, its effects on the inotropic response to alpha-adrenoceptor stimulation and its effects on the lusitropic effects of alpha- and beta-adrenoceptor stimulation are unknown. Methods: The effects of halothane (0.5 and 1 minimum alveolar concentration [MAC]) on the inotropic responses induced by phenylephrine (10(-8) to 10(-4) M) and isoproterenol (10(-8) to 10(-4) M) were studied in rat left ventricular papillary muscles in vitro (in Krebs-Henseleit solution at 29 degrees C, pH 7.40, with 0.5 mM calcium and stimulation frequency at 12 pulses/min). The lusitropic effects were studied in isotonic (R1) and isometric (R2) conditions. Results: One MAC halothane induced a negative inotropic effect (54 +/- 3%, P < 0.05), increased R1 (109 +/- 3%, P < 0.05), and decreased R2 (88 +/- 2%, P < 0.05). In control groups, phenylephrine (137 +/- 7%, P > 0.05) and isoproterenol (162 +/- 6%, P < 0.05) induced a positive inotropic effect. Halothane did not significantly modify the positive inotropic effect of calcium, suggesting that it did not modify the inotropic reserve of papillary muscles. In contrast, 1 MAC halothane enhanced the positive inotropic effects of phenylephrine (237 +/- 19%, P < 0.05) and isoproterenol(205 +/- 11%, P < 0.05). Halothane did not modify the lusitropic effect of phenylephrine under high or low load. In contrast, 1 MAC halothane impaired the positive lusitropic effect of isoproterenol under low load (P < 0.05), whereas it did not modify the positive lusitropic effect of isoproterenol under high load. Conclusions: At clinically relevant concentrations, halothane potentiated the positive inotropic effects of both (alpha- and beta-adrenoceptor stimulation. Furthermore, halothane alters the positive lusitropic effect of beta-adrenoceptor stimulation under low load.
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页码:147 / 159
页数:13
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