A Novel and Practical Continuous Flow Chemical Synthesis of Cannabidiol (CBD) and its CBDV and CBDB Analogues

被引：25

作者：

Chiurchiu, Elena ^{[1
]}

Sampaolesi, Susanna ^{[1
]}

Allegrini, Pietro ^{[2
]}

Ciceri, Daniele ^{[2
]}

Ballini, Roberto ^{[1
]}

Palmieri, Alessandro ^{[1
]}

机构：

[1] Univ Camerino, Green Chem Grp, Sch Sci & Technol, Div Chem, Via S Agostino 1, I-62032 Camerino, MC, Italy

[2] Indena SpA, Viale Ortles 12, I-20139 Milan, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 2021卷 / 08期

关键词：

Cannabidibutol; Cannabidiol; Cannabidivarin; Flow chemistry; Friedel-Crafts reaction; HASHISH; TETRAHYDROCANNABINOL; CANNABINOIDS; THC;

D O I：

10.1002/ejoc.202001633

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cannabidiol is one of the main non-psychoactive cannabinoids present in Cannabis sativa and, in the last decade, it is gaining great interest among the scientific community for its pharmaceutical, nutraceutical, and cosmetic applications. Herein, we report the first continuous flow chemical synthesis of cannabidiol (CBD) and its analogues cannabidivarin (CBDV) and cannabidibutol (CBDB). This approach permits to synthesize products in very good yields (55-59 %), limiting the formation of psychoactive and illegal cannabinoids such as tetrahydrocannabinol (THC).

引用

页码：1286 / 1289

页数：4

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