Effects of melatonin alone and in combination with inhibitor aceten on chronostructure of diurnal hemodynamic rhythms in patients with essential hypertension stage II

Aim. To study effects of monotherapy with melatonin and combination melatonin+aceten on circadian pattern of hemodynamics in patients with essential hypertension stage II. Materials and methods. 20 EH patients were randomized into 2 groups, 10 patients each. Group 1 patients were given melatonin alone (6 mg at 22.00). Group 2 received aceten (25 mg at 18.00) and melatonin (6 mg at 22.00). Before treatment and after 10 days of it, hemodynamic parameters were measured each 3 hours for 24 hours. Arterial pressure was measured by Korotkov method, heart rate - by ECG R-R interval, stroke volume - by tetrapolar chest rheography according to Kubichek. Cardiac index, total and specific peripheral resistance, double product were estimated routinely. Results. Internal and external dyssynchronism was registered in hemodynamic parameters of EH patients. Melatonin normalized circadian hemodynamic rhythms. It produced a hypotensive effect, reduced energy requirements of the myocardium. Combination of melatonin with aceten had a hypotensive and vasodilating effects but failed to restore circadian hemodynamic rhythms. Conclusion. Melatonin, epiphysial neurohormone, and its combination with aceten have hypotensive and vasodilating effects but melatonin monotherapy normalizes circadian hemodynamic rhythms while the combination was uneffective in this respect. This may be explained by interaction of melatonin and aceten actions.