Development and validation of a liquid chromatographic method for the analysis of capreomycin sulfate and its related substances

被引：9

作者：

Mallampati, Swapna ^{[1
]}

Huang, Shan ^{[1
]}

Ashenafi, Dunge ^{[1
]}

Van Hemelrijck, Elise ^{[1
]}

Hoogmartens, Jos ^{[1
]}

Adams, Erwin ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Lab Pharmaceut Anal, O&N 2, B-3000 Louvain, Belgium

来源：

JOURNAL OF CHROMATOGRAPHY A | 2009年 / 1216卷 / 12期

关键词：

Capreomycin sulfate; Impurities; LC;

D O I：

10.1016/j.chroma.2009.01.031

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A gradient LC method for the analysis of capreomycin sulfate and its related substances was developed. The chromatographic conditions include the use of a Hypersil base deactivated C-18 (250 mm x 4.6 mm, 5 mu m) column maintained at 25 degrees C, a mobile phase containing aceronitrile, phosphate buffer pH 2.3 and 0.025 M hexanesulfonate at a flow rate of 1.0 mL/min and UV detection performed at 268 nm. Good separation of the four active components of capreomycin and eleven unknown impurities was achieved. A system suitability test to check the quality of the separation is specified. The method shows good repeatability, linearity and robustness. (c) 2009 Elsevier B.V. All rights reserved.

引用

页码：2449 / 2455

页数：7

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