Juvenile Methylphenidate Exposure and Factors That Influence Incentive Processing

被引：20

作者：

Brenhouse, Heather C. ^{[1
]}

Napierata, Lee ^{[1
]}

Kussmaul, Lucinda ^{[1
]}

Leussis, Melanie ^{[1
]}

Andersen, Susan L. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, McLean Hosp, Lab Dev Neuropsychopharmacol,Dept Psychiat, Belmont, MA 02478 USA

来源：

DEVELOPMENTAL NEUROSCIENCE | 2009年 / 31卷 / 1-2期

关键词：

Place conditioning; Methylphenidate; Imprinting; Stimulant; CONDITIONED PLACE PREFERENCE; DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; BEHAVIORAL SENSITIZATION; SEX-DIFFERENCES; FEMALE RATS; LOCOMOTOR-ACTIVITY; PREFRONTAL CORTEX; NUCLEUS-ACCUMBENS; DOPAMINE TRANSPORTERS;

D O I：

10.1159/000207498

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Methylphenidate (MPH) is one of the few psychotropic agents approved for use in pediatric populations, underscoring the importance of elucidating any long-term consequences following exposure to this agent. Here, we examined the influence of several variables (i.e. age of assessment, age of exposure, sex, route of administration) on the effect of chronic low-dose MPH (2 mg/kg, twice daily) exposure on place conditioning to cocaine. Juvenile exposure to MPH, but not later exposure, resulted in aversions to cocaine-paired environments when assessed in young adult male rats, but not those entering adolescence. Juvenile MPH enhanced place preferences for cocaine-paired environments in female adolescent rats. The route of administration (i.p. injection or oral ingestion) did not produce enduring differential effects on behavior, and D-MPH was confirmed as the active enantiomer. These observations add to the growing literature on the enduring effects of MPH exposure, and highlight the need for more research in females. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：95 / 106

页数：12

共 73 条

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