Correlation Between Macular Integrity Assessment and Optical Coherence Tomography Imaging of Ellipsoid Zone in Macular Telangiectasia Type 2

被引：29

作者：

Mukherjee, Dibyendu ^{[1
]}

Lad, Eleonora M. ^{[2
]}

Vann, Ryan R. ^{[3
]}

Jaffe, Stephanie J. ^{[4
]}

Clemons, Traci E. ^{[5
]}

Friedlander, Martin ^{[6
,18
]}

Chew, Emily Y. ^{[7
]}

Jaffe, Glenn J. ^{[2
]}

Farsiu, Sina ^{[1
,2
]}

Sahel, Jose-Alain ^{[8
]}

Guymer, Robyn ^{[9
]}

Soubrane, Gisele ^{[10
]}

Gaudric, Alain ^{[11
]}

Schwartz, Steven ^{[12
]}

Constable, Ian ^{[13
]}

Cooney, Michael ^{[14
]}

Egan, Catherine ^{[15
]}

Singerman, Lawrence ^{[16
]}

Gillies, Mark C. ^{[17
]}

Friedlander, Martin ^{[6
,18
]}

Pauleikhoff, Daniel ^{[19
]}

Moisseiev, Joseph ^{[20
]}

Rosen, Richard ^{[21
]}

Murphy, Robert ^{[22
]}

Holz, Frank ^{[23
]}

Comer, Grant ^{[24
]}

Blodi, Barbara ^{[25
]}

Do, Diana ^{[26
]}

Brucker, Alexander ^{[27
]}

Narayanan, Raja ^{[28
]}

Wolf, Sebastian ^{[29
]}

Rosenfeld, Philip ^{[30
]}

Bernstein, Paul S. ^{[31
]}

Miller, Joan W. ^{[32
]}

机构：

[1] Duke Univ, Dept Biomed Engn, Med Ctr, Durham, NC 27706 USA

[2] Duke Univ, Med Ctr, Dept Ophthalmol, DUMC 3802, Durham, NC 27710 USA

[3] Res Triangle High Sch, Durham, NC USA

[4] Duke Univ, Trinity Coll, Durham, NC USA

[5] EMMES, Ophthalmol, Rockville, MD USA

[6] Scripps Res Inst, Dept Cell & Mol Biol, La Jolla, CA 92037 USA

[7] NEI, Div Epidemiol & Clin Applicat, Bethesda, MD USA

[8] Ctr Hop Natl Optalmol Quinze Vingts, Paris, France

[9] Ctr Eye Res, East Melbourne, Australia

[10] FEBO, Clin Ophtalmolgie Creteil, Creteil, France

[11] Hop Lariboisiere, Paris, France

[12] Univ Calif Los Angeles, Jules Stein Eye Inst, Los Angeles, CA 90024 USA

[13] Lions Eye Inst, Nedlands, WA, Australia

[14] Manhattan Eye Ear & Throat Hosp, New York, NY 10021 USA

[15] Moorfields Eye Hosp, London, England

[16] Retina Associates Cleveland, Cleveland, OH USA

[17] Save Sight Inst, Sydney, NSW, Australia

[18] Scripps Res Inst, La Jolla, CA 92037 USA

[19] St Franziskus Hosp, Munster, Germany

[20] Goldschleger Eye Inst, Tel Hashomer, Israel

[21] New York Eye & Ear Infirm, New York, NY 10003 USA

[22] Retina Grp Washington, Fairfax, VA USA

[23] Univ Bonn, Bonn, Germany

[24] Univ Michigan, Kellogg Eye Ctr, Ann Arbor, MI 48109 USA

[25] Univ Wisconsin, Madison, WI USA

[26] Wilmer Eye Inst, Baltimore, MD 21287 USA

[27] Scheie Eye Inst, Philadelphia, PA USA

[28] LV Prasad Eye Inst, Hyderabad, India

[29] Univ Bern, Bern, Switzerland

[30] Bascom Palmer, Miami, FL USA

[31] Univ Utah, Moran Eye Ctr, Salt Lake City, UT 84112 USA

[32] Harvard Med Sch, Massachusetts Eye & Ear Infirm, Boston, MA 02115 USA

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2017年 / 58卷 / 06期

关键词：

macular telangiectasia; microperimetry; optical coherence tomography; software; ellipsoid zone; RETINAL TELANGIECTASIS; AUTOMATIC SEGMENTATION; DISRUPTION; THICKNESS; MP1;

D O I：

10.1167/iovs.17-21834

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE. To correlate ellipsoid zone (EZ) defects on spectral-domain optical coherence tomography (SD-OCT) with retinal sensitivity loss on macular integrity assessment (MAIA) microperimetry in macular telangiectasia type 2 (MacTel). METHODS. Macular SD-OCT volumes and microperimetry maps were obtained during the international, multicenter, randomized phase 2 trial of ciliary neurotrophic factor for type 2 MacTel on two visits within 5 days of one another. Software was developed to register SD-OCT to MAIA scanning laser ophthalmoscopy images and to overlay EZ defect areas on the microperimetry maps generated from microperimetry sensitivity values at specific points and from interpolated sensitivity values. A total of 134 eyes of 67 patients were investigated. RESULTS. The semiautomated registration algorithm was found to be accurate, both qualitatively by visual inspection of the nearly perfect overlap of the retinal vessels and quantitatively as assessed by interobserver reliability metrics performed in 98 eyes of 49 patients (intraclass correlation of aggregate retinal sensitivity loss > 0.99). Aggregate retinal sensitivity loss within the EZ defect area was highly correlated with EZ defect area (Pearson correlation coefficient 0.93 and 0.92 at screening and baseline for noninterpolated maps; both were 0.94 for interpolated maps; P values < 0.001). CONCLUSIONS. With our software and image processing algorithms, there is nearly perfect correlation between retinal sensitivity on microperimetry and EZ defect area on SD-OCT. Our software allows determination of functional and structural changes with increasing disease severity and demonstrates that functional loss on microperimetry may be used as a surrogate marker of EZ loss on SD-OCT in type 2 MacTel.

引用

页码：291 / 299

页数：9

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