Basal cell carcinoma of the skin (part 1): epidemiology, pathology and genetic syndromes

被引：22

作者：

Correia de Sa, Tiago Ribeiro ^{[1
]}

Silva, Roberto ^{[1
]}

Lopes, Jose Manuel ^{[1
]}

机构：

[1] Univ Porto, Fac Med, P-4099002 Oporto, Portugal

来源：

FUTURE ONCOLOGY | 2015年 / 11卷 / 22期

关键词：

basal cell carcinoma; basal cell nevus syndrome; epidemiology; genetics; pathology; DUPRE-CHRISTOL-SYNDROME; INHERITED EPIDERMOLYSIS-BULLOSA; TRETINOIN CHEMOPREVENTION TRIAL; GORLIN SYNDROME; RISK-FACTORS; TRANSPLANT RECIPIENTS; CUTANEOUS MELANOMA; PROTEIN EXPRESSION; SUNLIGHT EXPOSURE; ACTINIC KERATOSIS;

D O I：

10.2217/fon.15.246

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Basal cell carcinoma (BCC) is the most common skin cancer worldwide with increasing incidence, but difficult to assess due to the current under registration practice. Despite the low mortality rate, BCC is a cause of great morbidity and an economic burden to health services. There are several risk factors that increase the risk of BCC and partly explain its incidence. Low-penetrance susceptibility alleles, as well as genetic alterations in signaling pathways, namely SHH pathway, also contribute to the carcinogenesis. BCC associate with several genetic syndromes, of which basal cell nevus syndrome is the most common.

引用

页码：3011 / 3021

页数：11

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