Advances in alkynyl gold complexes for use as potential anticancer agents

被引：59
作者：
Yang, Zhibin [1 ,2 ]
Jiang, Guizhi [1 ]
Xu, Zhongren [1 ]
Zhao, Sai [1 ]
Liu, Wukun [1 ,3 ,4 ]
机构：
[1] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Sch Med & Holist Integrat Med, Sch Pharm, Nanjing 210023, Peoples R China
[2] Dali Univ, Yunnan Prov Key Lab Entomol Biopharmaceut R&D, Innovat Team Adv Pharmaceut Entomol Biopharm R&D, Dali 671000, Peoples R China
[3] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210023, Peoples R China
[4] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China
来源：
COORDINATION CHEMISTRY REVIEWS | 2020年 / 423卷
基金：
中国国家自然科学基金;
关键词：
Alkynyl gold complexes; Anticancer; Mechanism; Structure-activity relationship; HETEROCYCLIC CARBENE COMPLEXES; IN-VITRO; METAL-COMPLEXES; BIOLOGICAL-PROPERTIES; GOLD(III) COMPLEXES; PROTEOMIC ANALYSIS; CANCER-CELLS; COPPER(II) COMPLEXES; PHOSPHINE COMPLEXES; PLATINUM ANTICANCER;
D O I：
10.1016/j.ccr.2020.213492
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Gold-based anticancer agents have gained the widespread attention of medicinal inorganic chemists due to their unique chemical properties and strong antiproliferative potency. Among different families of gold complexes, alkynyl gold complexes with a general structure of R-C C-Au-L have been intensely investigated for use as anticancer agents. These complexes are well documented and usually exhibited a significant stability in vitro. The variation in the ligand brings about the diversity of biological properties of alkynyl gold complexes and their proven mechanisms of action mainly include one or more kinds of processes, including thioredoxin reductase (TrxR) inhibition, DNA destruction, cell cycle arrest, apoptosis induction, etc. In this review, the current understanding of structure-activity relationships (SARs), mode of action and cytotoxicity of alkynyl gold complexes were summarized. (C) 2020 Elsevier B.V. All rights reserved.
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页数：23
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