Effects of IgG and IgM autoantibodies on non-infected erythrocytes is related to ABO blood group in Plasmodium vivax malaria and is associated with anemia

被引：4

作者：

Mourao, Luiza Carvalho ^{[1
]}

Pantuzzo Medeiros, Camila Maia ^{[1
]}

Cardoso-Oliveira, Gustavo Pereira ^{[1
]}

da Silva Roma, Paula Magda ^{[2
]}

Sultane Aboobacar, Jamila da Silva ^{[1
]}

Medeiros Rodrigues, Beatriz Carolina ^{[1
]}

Agero, Ubirajara ^{[2
]}

Fernandes Fontes, Cor Jesus ^{[3
]}

Braga, Erika Martins ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Parasitol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Phys, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Mato Grosso, Sch Med Sci, BR-78060900 Cuiaba, MT, Brazil

来源：

MICROBES AND INFECTION | 2020年 / 22卷 / 08期

关键词：

Plasmodium vivax; ABO blood groups; IgG; IgM; Phagocytosis; Membrane deformability; SUSCEPTIBILITY;

D O I：

10.1016/j.micinf.2020.02.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoantibodies play an important role in the destruction of non-infected red blood cells (nRBCs) during malaria. However, the relationship between this clearance and ABO blood groups is yet to be fully enlightened, especially for Plasmodium vivax infections. Here we show that anti-RBC IgG and IgM are increased in anemic patients with acute vivax malaria. Furthermore, both antibodies are able to decrease the deformability of nRBCs, but only IgG can induce in vitro erythrophagocytosis. Such effects are enhanced in type O erythrocytes, suggesting that individuals from this blood group infected with P. vivax malaria may be more susceptible to develop anemia. (C) 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：379 / 383

页数：5

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