Oligomer formation of a tea polyphenol, EGCG, on its sensing molecule 67 kDa laminin receptor

被引：18

作者：

Huang, Yuhui ^{[1
]}

Sumida, Mami ^{[1
]}

Kumazoe, Motofumi ^{[1
]}

Sugihara, Kaori ^{[1
]}

Suemasu, Yumi ^{[1
]}

Yamada, Shuhei ^{[1
]}

Yamashita, Shuya ^{[1
]}

Miyakawa, Jyunichi ^{[2
]}

Takahashi, Takashi ^{[3
]}

Tanaka, Hiroshi ^{[2
]}

Fujimura, Yoshinori ^{[1
]}

Tachibana, Hirofumi ^{[1
]}

机构：

[1] Kyushu Univ, Fac Agr, Dept Biosci & Biotechnol, Div Appl Biol Chem,Higashi Ku, 6-10-1 Hakozaki, Fukuoka 8128581, Japan

[2] Tokyo Inst Technol, Grad Sch Sci & Engn, Dept Appl Chem, Meguro Ku, 2-12-1 Ookayama, Tokyo 1528552, Japan

[3] Yokohama Coll Pharm, Totsuka Ku, 601 Matana Cho, Yokohama, Kanagawa 2450066, Japan

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 12期

关键词：

ISOTHERMAL TITRATION CALORIMETRY; CELL-SURFACE BINDING; (-)-EPIGALLOCATECHIN GALLATE; EPIGALLOCATECHIN-3-GALLATE; PROCYANIDINS; METABOLISM; MODEL; ACTIVATION; MECHANISMS; MICROBIOTA;

D O I：

10.1039/c6cc09504f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) has been attributed to the activation of its cell surface sensing receptor 67 kDa laminin receptor (67LR). However, the action of EGCG to activate 67LR remains unknown. Here we show that EGCG undergoes oligomer formation on its surface receptor 67LR.

引用

页码：1941 / 1944

页数：4

共 36 条

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