Coronary endothelial dysfunction: from pathogenesis to clinical implications

被引：10

作者：

Bockus, Lee ^{[1
]}

Kim, Francis ^{[1
]}

机构：

[1] Univ Washington, Dept Med, Seattle, WA 98195 USA

来源：

OPEN HEART | 2022年 / 9卷 / 02期

关键词：

Microvascular Angina; RISK FACTORS; CORONARY ARTERY DISEASE; Atherosclerosis; FLOW-MEDIATED DILATION; NITRIC-OXIDE; OXIDATIVE STRESS; ARTERY-DISEASE; INCREASED RISK; ATHEROSCLEROSIS; PREVALENCE; BETA;

D O I：

10.1136/openhrt-2022-002200

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endothelial dysfunction (ED) has a substantial role in the pathogenesis of atherosclerosis and other vascular diseases. Multiple risk factors, including smoking, hyperlipiadaemia and diabetes, can have associated ED, which is correlated with cardiac events. Measurement of coronary artery endothelial function requires the use of invasive techniques to assess both epicardial coronary artery and microvascular beds. Peripheral vascular techniques and endothelial biomarkers can be used to indirectly assess coronary ED. In this review of coronary artery ED, we discuss the current state of the field, the techniques used to measure ED and its clinical implications.

引用

页数：7

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