Synthesis of Tetrahydroisoindolinones via a Metal-Free Dehydrogenative Diels-Alder Reaction

被引：14

作者：

Xu, Wen-Lei ^{[1
]}

Tang, Lei ^{[1
]}

Ge, Chen-Yu ^{[1
]}

Chen, Jie ^{[1
]}

Zhou, Ling ^{[1
]}

机构：

[1] Northwest Univ, Natl Demonstrat Ctr Expt Chem Educ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem,Minist Educ, Xian 710127, Shaanxi, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 10期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

alkenes; cycloaddition; Diels-Alder reaction; dehydrogenation; NATURAL-PRODUCTS; DERIVATIVES; 1,3-DIENES; HYDROGEN; SERIES;

D O I：

10.1002/adsc.201801436

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A metal-free dehydrogenative Diels-Alder reaction of substituted alkenes for the synthesis of tetrahydroisoindolinones has been exploited for the first time. This new method features functional group tolerance and broad substrate scope, providing an efficient access to biologically active tetrahydroisoindolinone skeletons with endo steroselectivity in good to excellent yields.

引用

页码：2268 / 2273

页数：6

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