Niosomes from glucuronic acid-based surfactant as new carriers for cancer therapy: Preparation, characterization and biological properties

被引：51
作者：
Tavano, Lorena [1 ,2 ]
Aiello, Rossana [3 ]
Ioele, Giuseppina [1 ]
Picci, Nevio [1 ]
Muzzalupo, Rita [1 ]
机构：
[1] Univ Calabria, Dipartimento Farm & Sci Salute & Nutr, I-87036 Cosenza, Italy
[2] Univ Calabria, Dipartimento Ingn Informat Modellist Elettron & S, I-87036 Cosenza, Italy
[3] Magna Graecia Univ Catanzaro, Dipartimento Sci Salute, I-88100 Catanzaro, Italy
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2014年 / 118卷
关键词：
Glucuronic acid; Niosomes; Doxorubicin; 5-Fluorouracil; Hemolysis; DRUG-DELIVERY; VESICLES NIOSOMES; STABILITY; CHOLESTEROL; DOXORUBICIN; METHOTREXATE; TRANSFERRIN; DERIVATIVES; LIPOSOMES;
D O I：
10.1016/j.colsurfb.2014.03.016
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Niosomes are vesicular systems composed of surfactant molecules, claimed to be used as drug delivery carriers thanks to their physico-chemical and biological properties. The aim of this work was to design niosomes obtained with a surfactant synthesized from glucuronic acid. Doxorubicin and 5FU were used as model drugs. Niosomes were prepared with different ratios between surfactant and cholesterol, and characterized in terms of size, morphology, drugs entrapment efficiency and in vitro releases, to identify the optimal formulation to be used in pharmaceutical fields. In addition, the hemolytic activity of all formulations have been also evaluated. Results showed that dodecylglucuronamide surfactant was able to produce vesicular systems with or without the presence of cholesterol. Niosomes resulted regular in size and shape and they have been found to encapsulate and release in a controlled manner both doxorubicin and 5-fluorouracil. Hemolytic tests showed that the capability of disrupting erythrocyte only depend on the size of colloidal aggregates. Finally, our formulations could be potentially used as antitumoral delivery systems in anticancer therapy. (C) 2014 Elsevier B.V. All rights reserved.
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页码：7 / 13
页数：7
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